Hypertension: a complication of danazol therapy

J A Bretza, Bretza JA, J Bretza, Novey HS, H S Novey, Vaziri ND, N D Vaziri, Warner AS, A S Warner
Archives of internal medicine · 1980 · vol. 140(10) , pp. 1379–1380 · doi:10.1001/archinte.140.10.1379 · PMID:7425772 · W1985134084
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This paper reports a case of volume-dependent hypertension in a patient treated with danazol for hereditary angioedema, which resolved with diuretic therapy.

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Abstract

Danazol is a semisynthetic androgen that is used in the treatment of endometriosis and hereditary angioedema. Although fluid retention and weight gain are well-known complictaions of danazol therapy, to our knowledge hypertension has not been previously documented with the use of this drug. We have studied a patient with hereditary angioedema who exhibited a reproducible hypertension with danazol therapy. Based on our investigation, the resultant hypertension was primarily volume dependent. The hypertension in this patient failed to respond to propranolol hydrochloride, while it normalized with the administration of a small dose of a diuretic. In view of the growing indications for therapy with danazol, increasing numbers of susceptible patients may be at risk of having drug-induced hypertension develop. We, therefore, recommend that blood pressure be routinely monitored in patients receiving this drug.

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Condition tags

endometriosis

MeSH descriptors

Danazol Hypertension Pregnadienes Adult Adult Blood Pressure Blood Pressure Body Weight Body Weight Body Weight Danazol Danazol Humans Humans Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide Hypertension Hypertension Male

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