Endometriosis and mullerian anomalies

David L. Olive, D L Olive, Olive DL, D Y Henderson, Henderson DY
Obstetrics and gynecology · 1987 · vol. 69(3 Pt 1) , pp. 412–5 · PMID:3822289 · W2336911662
Observational OA: closed CC0 ⤵ 149 in-corpus citations
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This study evaluated women with Müllerian anomalies and found that the presence of endometriosis correlated with outflow obstruction, patent tubes, and hematocolpos/hematometra, supporting increased retrograde menstruation as a factor in endometriosis development.

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Abstract

Although numerous etiologies for endometriosis have been proposed, it is clear that retrograde menstruation and cell-mediated lymphocytotoxicity each play a significant role in the disease's development. A comprehensive theory of pathogenesis of endometriosis holds that development of the disorder depends upon amount of retrograde menstruation and the ability of the immune response to remove the debris. To test this theory, 64 women with mullerian anomalies and intra-abdominal surgery were evaluated for the presence or absence of endometriosis, patency of tubes, hematocolpos or hematometra, and outflow obstruction. Results demonstrated that endometriosis was present in ten of 13 women with functioning endometrium, patent tubes, and outflow obstruction, whereas it could be identified in only 16 of 43 women with no obstruction (77 versus 37%, P less than .01). Similarly, eight of nine women with hematocolpos or hematometra had endometriosis, while only 18 of 47 with functioning endometrium but no hematometra/hematocolpos had it (89 versus 38%, P less than .01). None of the eight women without endometrium had endometriosis. These data support the concept that an increase in retrograde menstruation will increase the likelihood of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Menstruation Disturbances Mullerian Ducts Mullerian Ducts Uterus Endometriosis Endometriosis Fallopian Tube Patency Tests Fallopian Tube Patency Tests Female Female Humans Humans Menstruation Disturbances Menstruation Disturbances Risk Risk Uterus Uterus

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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