Epithelial-mesenchymal transition links inflammation and fibrosis in the pathogenesis of endometriosis: a narrative review

Zoé I. Vincent‐Mistiaen

doi:10.1016/j.xfnr.2025.100089

Epithelial-mesenchymal transition links inflammation and fibrosis in the pathogenesis of endometriosis: a narrative review

Zoé I. Vincent‐Mistiaen

In: F&S Reviews · 2025 · vol. 6(1) , pp. 100089 · doi:10.1016/j.xfnr.2025.100089 · W4407596764

Review OA: closed CC0 ⤵ 1 in-corpus citation

🔓 Open OA copy View on OpenAlex View at publisher

⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This review explores how epithelial-mesenchymal transition connects inflammation and fibrosis in the development of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Adhesions and endometriosis: challenges in subfertility management : (An expert opinion of the ANGEL-The ANti-Adhesions in Gynaecology Expert PaneL-group) via openalex
A high level of TGF-B1 promotes endometriosis development via cell migration, adhesiveness, colonization, and invasiveness† via openalex
Altered differentiation of endometrial mesenchymal stromal fibroblasts is associated with endometriosis susceptibility via openalex
Analysis of menstrual effluent: diagnostic potential for endometriosis via openalex
Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology via openalex
Assessment of BMP7, SMAD4, and CDH1 Expression Profile and Regulatory miRNA-542-3p in Eutopic and Ectopic Endometrium of Women with Endometriosis via openalex
Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis via openalex
Bowel endometriosis: Recent insights and unsolved problems via openalex
Cellular Changes Consistent With Epithelial-Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex
Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway via openalex
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium via openalex
Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis via openalex
Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis via openalex
CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling via openalex
E2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis via openalex
EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression via openalex
Endometriosis via openalex
Endometriosis via openalex
Endometriosis via openalex
Endometriosis: Cellular and Molecular Mechanisms Leading to Fibrosis via openalex
Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis via openalex
Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients via openalex
Epithelial-to-mesenchymal transition contributes to the downregulation of progesterone receptor expression in endometriosis lesions via openalex
Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior via openalex
Exploring Epithelial-Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes via openalex
Expression of ZEB1 in different forms of endometriosis: A pilot study via openalex
Fibroblast growth factor receptor 2 promotes the proliferation, migration, and invasion of ectopic stromal cells via activation of extracellular-signal-regulated kinase signaling pathway in endometriosis via openalex
Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis via openalex
Genetics and Inflammation in Endometriosis: Improving Knowledge for Development of New Pharmacological Strategies via openalex
Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis via openalex
ILK enhances migration and invasion abilities of human endometrial stromal cells by facilitating the epithelial-mesenchymal transition via openalex
Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis via openalex
Independent development of endometrial epithelium and stroma within the same endometriosis via openalex
Interleukin-6, interleukin-1β, and tumor necrosis factor α in menstrual effluents as biomarkers of chronic endometritis via openalex
Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development via openalex
JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis via openalex
Lipoxin A4 Suppresses Estrogen-Induced Epithelial-Mesenchymal Transition via ALXR-Dependent Manner in Endometriosis via openalex
Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1 via openalex
Melatonin inhibits 17β-estradiol-induced migration, invasion and epithelial-mesenchymal transition in normal and endometriotic endometrial epithelial cells via openalex
Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition via openalex
Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis via openalex
microRNA-141 inhibits TGF-β1-induced epithelial-to-mesenchymal transition through inhibition of the TGF-β1/SMAD2 signalling pathway in endometriosis via openalex
Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes via openalex
Mutation and methylation profiles of ectopic and eutopic endometrial tissues via openalex
Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex
New concepts on the etiology of endometriosis via openalex
P-343 Metformin reduces endometrial implants and improves fertility in a mouse model of endometriosis via openalex
PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis via openalex
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells via openalex
Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence via openalex
Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex
Platelets induce endothelial-mesenchymal transition and subsequent fibrogenesis in endometriosis via openalex
Progressive development of endometriosis and its hindrance by anti-platelet treatment in mice with induced endometriosis via openalex
Proteome analysis of human mesothelial cells during epithelial to mesenchymal transitions induced by shed menstrual effluent via openalex
Reduction of apoptosis and proliferation in endometriosis via openalex
Roles of cell migration and invasion mediated by Twist in endometriosis via openalex
Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis via openalex
Similar Characteristics of Endometrial and Endometriotic Epithelial Cells via openalex
Smooth muscle metaplasia and innervation in interstitium of endometriotic lesions related to pain via openalex
Smooth muscles are frequent components of endometriotic lesions via openalex
Specific Local Predictors That Reflect the Tropism of Endometriosis-A Multiple Immunohistochemistry Technique via openalex
"Spot"-ting differences between the ectopic and eutopic endometrium of endometriosis patients via openalex
TET1 may contribute to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis via openalex
The establishment of a mouse model of deep endometriosis via openalex
The Main Theories on the Pathogenesis of Endometriosis via openalex
The Presence of Endometrial Cells in Peritoneal Fluid of Women With and Without Endometriosis via openalex
Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice via openalex
Uterine bleeding: how understanding endometrial physiology underpins menstrual health via openalex
What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis? via openalex
Whole-exome sequencing and functional validation reveal a rare missense variant in MMP7 that confers ovarian endometriosis risk via openalex
ZEB1 expression is a potential indicator of invasive endometriosis via openalex
W3018913922 via openalex
W2509675510 via openalex
W2406042991 via openalex
W2336099036 via openalex
W3099845593 via openalex
W3104079531 via openalex
W2302589752 via openalex
W3169899682 via openalex
W2171875732 via openalex
W2168986165 via openalex
W2168826120 via openalex
W3197525499 via openalex
W3199580082 via openalex
W3202915246 via openalex
W2159835130 via openalex
W2155116729 via openalex
W4210985239 via openalex
W2142120438 via openalex
W4211081176 via openalex
W4211233744 via openalex
W1215049722 via openalex
W4224230247 via openalex
W2103771206 via openalex
W2088876544 via openalex
W2072503088 via openalex
W2063011414 via openalex
W4294992918 via openalex
W2054226475 via openalex

Cited by (2)

Source provenance

openalex: last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall: last seen: 2026-08-14T06:25:32.811723+00:00

License: CC0 · commercial use OK

[1] Adhesions and endometriosis: challenges in subfertility management : (An expert opinion of the ANGEL-The ANti-Adhesions in Gynaecology Expert PaneL-group) via openalex

[2] A high level of TGF-B1 promotes endometriosis development via cell migration, adhesiveness, colonization, and invasiveness† via openalex

[3] Altered differentiation of endometrial mesenchymal stromal fibroblasts is associated with endometriosis susceptibility via openalex

[4] Analysis of menstrual effluent: diagnostic potential for endometriosis via openalex

[5] Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology via openalex

[6] Assessment of BMP7, SMAD4, and CDH1 Expression Profile and Regulatory miRNA-542-3p in Eutopic and Ectopic Endometrium of Women with Endometriosis via openalex

[7] Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis via openalex

[8] Bowel endometriosis: Recent insights and unsolved problems via openalex

[9] Cellular Changes Consistent With Epithelial-Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex

[10] Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway via openalex

[11] Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium via openalex

[12] Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis via openalex

[13] Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis via openalex

[14] CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling via openalex

[15] E2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis via openalex

[16] EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression via openalex

[17] Endometriosis via openalex

[18] Endometriosis via openalex

[19] Endometriosis via openalex

[20] Endometriosis: Cellular and Molecular Mechanisms Leading to Fibrosis via openalex

[21] Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis via openalex

[22] Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients via openalex

[23] Epithelial-to-mesenchymal transition contributes to the downregulation of progesterone receptor expression in endometriosis lesions via openalex

[24] Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior via openalex

[25] Exploring Epithelial-Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes via openalex

[26] Expression of ZEB1 in different forms of endometriosis: A pilot study via openalex

[27] Fibroblast growth factor receptor 2 promotes the proliferation, migration, and invasion of ectopic stromal cells via activation of extracellular-signal-regulated kinase signaling pathway in endometriosis via openalex

[28] Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis via openalex

[29] Genetics and Inflammation in Endometriosis: Improving Knowledge for Development of New Pharmacological Strategies via openalex

[30] Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis via openalex

[31] ILK enhances migration and invasion abilities of human endometrial stromal cells by facilitating the epithelial-mesenchymal transition via openalex

[32] Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis via openalex

[33] Independent development of endometrial epithelium and stroma within the same endometriosis via openalex

[34] Interleukin-6, interleukin-1β, and tumor necrosis factor α in menstrual effluents as biomarkers of chronic endometritis via openalex

[35] Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development via openalex

[36] JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis via openalex

[37] Lipoxin A4 Suppresses Estrogen-Induced Epithelial-Mesenchymal Transition via ALXR-Dependent Manner in Endometriosis via openalex

[38] Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1 via openalex

[39] Melatonin inhibits 17β-estradiol-induced migration, invasion and epithelial-mesenchymal transition in normal and endometriotic endometrial epithelial cells via openalex

[40] Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition via openalex

[41] Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis via openalex

[42] microRNA-141 inhibits TGF-β1-induced epithelial-to-mesenchymal transition through inhibition of the TGF-β1/SMAD2 signalling pathway in endometriosis via openalex

[43] Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes via openalex

[44] Mutation and methylation profiles of ectopic and eutopic endometrial tissues via openalex

[45] Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex

[46] New concepts on the etiology of endometriosis via openalex

[47] P-343 Metformin reduces endometrial implants and improves fertility in a mouse model of endometriosis via openalex

[48] PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis via openalex

[49] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[50] PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells via openalex

[51] Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence via openalex

[52] Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex

[53] Platelets induce endothelial-mesenchymal transition and subsequent fibrogenesis in endometriosis via openalex

[54] Progressive development of endometriosis and its hindrance by anti-platelet treatment in mice with induced endometriosis via openalex

[55] Proteome analysis of human mesothelial cells during epithelial to mesenchymal transitions induced by shed menstrual effluent via openalex

[56] Reduction of apoptosis and proliferation in endometriosis via openalex

[57] Roles of cell migration and invasion mediated by Twist in endometriosis via openalex

[58] Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis via openalex

[59] Similar Characteristics of Endometrial and Endometriotic Epithelial Cells via openalex

[60] Smooth muscle metaplasia and innervation in interstitium of endometriotic lesions related to pain via openalex

[61] Smooth muscles are frequent components of endometriotic lesions via openalex

[62] Specific Local Predictors That Reflect the Tropism of Endometriosis-A Multiple Immunohistochemistry Technique via openalex

[63] "Spot"-ting differences between the ectopic and eutopic endometrium of endometriosis patients via openalex

[64] TET1 may contribute to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis via openalex

[65] The establishment of a mouse model of deep endometriosis via openalex

[66] The Main Theories on the Pathogenesis of Endometriosis via openalex

[67] The Presence of Endometrial Cells in Peritoneal Fluid of Women With and Without Endometriosis via openalex

[68] Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice via openalex

[69] Uterine bleeding: how understanding endometrial physiology underpins menstrual health via openalex

[70] What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis? via openalex

[71] Whole-exome sequencing and functional validation reveal a rare missense variant in MMP7 that confers ovarian endometriosis risk via openalex

[72] ZEB1 expression is a potential indicator of invasive endometriosis via openalex

[73] W3018913922 via openalex

[74] W2509675510 via openalex

[75] W2406042991 via openalex

[76] W2336099036 via openalex

[77] W3099845593 via openalex

[78] W3104079531 via openalex

[79] W2302589752 via openalex

[80] W3169899682 via openalex

[81] W2171875732 via openalex

[82] W2168986165 via openalex

[83] W2168826120 via openalex

[84] W3197525499 via openalex

[85] W3199580082 via openalex

[86] W3202915246 via openalex

[87] W2159835130 via openalex

[88] W2155116729 via openalex

[89] W4210985239 via openalex

[90] W2142120438 via openalex

[91] W4211081176 via openalex

[92] W4211233744 via openalex

[93] W1215049722 via openalex

[94] W4224230247 via openalex

[95] W2103771206 via openalex

[96] W2088876544 via openalex

[97] W2072503088 via openalex

[98] W2063011414 via openalex

[99] W4294992918 via openalex

[100] W2054226475 via openalex