Similar Characteristics of Endometrial and Endometriotic Epithelial Cells

Lutz Konrad, Judith Gronbach, Fabian Horné, Ezekiel Mecha, Ezekiel O Mecha, Enikő Berkes, Eniko Berkes, Matthias Frank, Stefan Gattenlöhner, Charles O A Omwandho, Frank Oehmke, Hans‐Rudolf Tinneberg, Hans-Rudolf Tinneberg
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 26(1) , pp. 49–59 · doi:10.1177/1933719118756745 · PMID:29402201 · W2786876442
article OA: closed CC0 ⤵ 18 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This study compared epithelial and mesenchymal markers in eutopic endometrium and endometriotic lesions, finding maintained epithelial phenotypes and suggesting partial EMT plays a role in endometriosis development.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The study examined whether epithelial-mesenchymal transition (EMT) occurs in endometriosis by comparing epithelial and mesenchymal marker expression in eutopic endometrium versus three endometriotic entities: peritoneal, ovarian, and deep infiltrating endometriosis (DIE). Using markers keratin-18, keratin-19, MUC1, vimentin, and ZEB1, the authors found no differences in K18 between endometrium and lesions, and no differences for K18, K19, or MUC1 overall when eutopic endometrium was compared with endometriosis; however, K19 and MUC1 were modestly but significantly decreased in endometriotic lesions. They observed maintained epithelial marker expression overall, with reduced epithelial vimentin in endometriotic lesions (contrasting with reported increases in stromal vimentin) and increased ZEB1 especially in DIE, suggesting possible partial EMT. The paper concludes that EMT is not a main factor in endometriosis pathogenesis. This paper is centrally about endometriosis — it directly tests EMT-related epithelial versus mesenchymal phenotypes across eutopic endometrium and peritoneal, ovarian, and deep infiltrating endometriosis lesions.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Epithelial Cells Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelial-Mesenchymal Transition Female Humans Keratin-18 Keratin-18 Keratin-19 Keratin-19 Mesoderm Mesoderm Mucin-1 Mucin-1

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