COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic pain

Olaf Buchweitz, Buchweitz O, Annette Staebler, Staebler A, Wülfing P, Pia Wülfing, P Wülfing, Hauzman E, Erik Hauzman, Greb R, Robert Greb, Kiesel L, Ludwig Kiesel
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 124(2) , pp. 216–221 · doi:10.1016/j.ejogrb.2005.09.016 · PMID:16309818 · W2165176646
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This study found that increased cyclooxygenase-2 expression in peritoneal lesions correlates with the presence of nonmenstrual chronic pelvic pain.

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Abstract

OBJECTIVE: To investigate cyclooxygenase (COX-2) expression within different endometriotic lesions and to assess whether these expression patterns correlate with clinical characteristics. DESIGN: Retrospective cross-sectional study. SETTING: University Hospital. PATIENTS: Seventy patients with histologically confirmed exclusively peritoneal (n=20), ovarian (n=19) or deep-infiltrating (n=31) endometriosis and a detailed medical history. INTERVENTION: Immunohistochemical analysis for COX-2 was performed on 108 endometriotic lesions. MEASUREMENTS AND MAIN RESULTS: COX-2 intensity, percentage of stained glandular endometriotic cells, and correlation of COX-2 expression with clinicopathological parameters. Semiquantitative COX-2 expression did not differ between distinct morphological types of endometriosis and showed no association with the menstrual cycle. Patients with peritoneal-only endometriosis suffering from moderate or severe chronic pelvic pain showed significantly more frequent COX-2 overexpression than asymptomatic patients or patients with minimal symptoms. In patients with exclusively ovarian or deep-infiltrating endometriosis no association between COX-2 expression and clinical parameters, such as chronic pelvic pain, dysmenorrhoea, dyspareunia, sterility, lower urinary tract symptoms or gastrointestinal symptoms was observed. CONCLUSION: Peritoneal endometriotic lesions with increased COX-2 expression have a special relevance for the development of chronic, nonmenstruation-associated, pelvic pain in endometriotic patients. These patients may benefit from therapy with COX-2 inhibitors.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Cyclooxygenase 2 Endometriosis Pelvic Pain Peritoneal Cavity Peritoneal Diseases Chronic Disease Chronic Disease Cross-Sectional Studies Cross-Sectional Studies Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Female Female Humans Humans Immunohistochemistry

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