Increased frequency of human leukocyte antigen-E inhibitory receptor CD94/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis

Ricciarda Galandrini, Galandrini R, Maria Grazia Porpora, Antonella Stoppacciaro, Federica Micucci, Micucci F, Cristina Capuano, Alessia Di Felice, Ilaria Tassi, Di Felice A, Pierluigi Benedetti Panici, Pierluigi Benedetti-Panici, Benedetti-Panici P, Angela Santoni, Santoni A
Fertility and sterility · 2007 · vol. 89(5) , pp. 1490–1496 · doi:10.1016/j.fertnstert.2007.05.018 · PMID:17706207 · W2003703920
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This study investigated the frequency of CD94/NKG2A-expressing peritoneal natural killer cells in endometriosis patients, finding an increased frequency compared to controls.

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Abstract

OBJECTIVE: To analyze the frequency of peritoneal natural killer (NK) cells expressing the human leukocyte antigen (HLA)-E receptor CD94/NKG2A in patients with endometriosis. DESIGN: Case-control study. SETTING: University hospital. PATIENT(S): Stage III and stage IV endometriosis, according to the revised American Society for Reproductive Medicine classification, was laparoscopically and histologically confirmed in 11 and 9 patients, respectively; 13 subjects without endometriosis were selected for the control group. INTERVENTION(S): Collection of peripheral venous blood, peritoneal fluid, endometriotic tissue, and normal endometrium in subjects undergoing laparoscopy. MAIN OUTCOME MEASURE(S): Surface expression levels of CD94/NKG2A and CD94/NKG2C were detected by three-color cytofluorometric analysis. Semiquantitative HLA-E messenger RNA expression analysis was performed in endometriotic lesions and in eutopic endometrium. NK cell-mediated cytotoxic activity toward HLA-E positive target, DT360 cell line, was also determined. RESULT(S): In women with endometriosis, the percentage of CD94/NKG2A-positive peritoneal NK cells was significantly higher than in the control group. The CD94/NKG2A ligand, HLA-E, was detected at high levels in endometriotic tissue as messenger RNA transcript. Target cells bearing HLA-E were resistant to NK cell-mediated lysis in a CD94/NKG2A-dependent manner. CONCLUSION(S): Increased expression of CD94/NKG2A in peritoneal NK cells may mediate the resistance of endometriotic tissue to NK cell-mediated lysis, thus contributing to the progression of the disease.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Killer Cells, Natural NK Cell Lectin-Like Receptor Subfamily D Receptors, Immunologic Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Case-Control Studies Case-Control Studies Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (37)

Cited by (39)

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