Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis

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This study investigated lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis.

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Abstract

OBJECTIVE: To analyze the lymph node involvement by endometriotic foci in rectosigmoid endometriosis and to correlate it with clinical and histological parameters including the presence of lymphovascular invasions, which could explain this lymph node involvement. DESIGN: A prospective study of 26 consecutive cases of rectosigmoid endometriosis between January 2005 and January 2007. SETTING: A multidisciplinary study including clinical and pathological data. PATIENT(S): Twenty-six patients with symptomatic rectosigmoid endometriosis. INTERVENTION(S): Laparoscopic surgery with pathological analysis of each specimen. MAIN OUTCOME MEASURE(S): Involvement of lymph nodes by endometriotic foci was correlated with the size and the wall layers affected by endometriotic lesions, the number of lymph nodes retrieved, and the presence of lymphovascular invasions demonstrated by D2-40, a specific antibody to lymphatic vessels. RESULT(S): Lymph node involvement by endometriosis was observed in 11 of the 26 patients (42.3%) and correlated with the size of the lesions, the number of lymph nodes retrieved, and the presence of lymphovascular invasions, which were observed in 36.3% of cases. CONCLUSION(S): Our data confirm that lymph node involvement by endometriotic foci is a frequent event in rectosigmoid endometriosis and may result at least partially from a lymphatic spread of the disease.

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Condition tags

endometriosis

MeSH descriptors

Colon Endometriosis Lymphangiogenesis Lymphatic Vessels Lymph Nodes Rectum Adult Adult Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Antibodies, Monoclonal, Murine-Derived Biomarkers Biomarkers Biomarkers Colon Colon Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (50)

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europepmc
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openalex
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License: CC0 · commercial use OK