The Relationship of Circular RNAs With Ovarian Endometriosis

Xiaoxuan Xu, Xu X, Shuangzheng Jia, Shuang-Zheng Jia, Dai Y, Yi Dai, Zhang JJ, Jun-Ji Zhang, Junji Zhang, Xiaoyan Li, Li X, Shi J, Jinghua Shi, Leng J, Jinhua Leng, Jinghe Lang, Lang J
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 25(8) , pp. 1292–1300 · doi:10.1177/1933719118759439 · PMID:29490568 · W2794235831
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This study profiled circular RNA and mRNA expression in ovarian endometriosis, identifying differentially expressed circRNAs and mRNAs involved in immune-inflammatory responses and cell cycle regulation, and constructed a circRNA-miRNA-mRNA network suggesting roles for cancer-related pathways.

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Abstract

Circular RNAs (circRNAs) are involved in the pathogenesis of many diseases, although their expression pattern and role in endometriosis remains unknown. Therefore, here, we profiled the expression patterns of circRNAs in ovarian ectopic and paired eutopic endometria as well as constructed a circRNA-miRNA-mRNA network. Circular RNA and messenger RNA (mRNA) expression profiles were assessed by a microarray analysis in 4 patients. Quantitative real-time polymerase chain reaction (qRT-PCR) validation of 8 circRNAs and mRNAs was conducted in another 37 patients. We detected 1258 up- and 1061 downregulated circRNAs as well as 1900 up- and 2535 downregulated mRNAs between the ectopic and eutopic endometria. Functional analysis suggested that most differentially expressed mRNAs participate in immune-inflammatory responses and cell cycle regulation. The qRT-PCR validation results for 5 circRNAs ( circ_0004712, circ_0002198, circ_0003570, circ_0008951, and circ_0017248) and 8 mRNAs ( SCN3B, ENTPD1, IL16, BACH2, C3, CKS2, G0S2, and PGRMC1) matched the microarray results. On basis of target prediction, we constructed a circRNA-miRNA-mRNA network. This revealed the primary roles of cancer-related, purine metabolism, glycerophospholipid metabolism, and thyroid hormone signaling pathways in endometriosis pathogenesis. This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis RNA Adult Adult Biomarkers Biomarkers Biomarkers Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Gene Expression Profiling Gene Expression Profiling Gene Expression Regulation Gene Expression Regulation Humans Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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