"Medical oophorectomy" using a long-acting GNRH agonist--a possible new approach to the treatment of endometriosis

David R. Meldrum, Meldrum DR, D R Meldrum, R. Jeffrey Chang, Chang RJ, R J Chang, John Lu, Lu J, J Lu, Wylie Vale, Vale W, W Vale, J. Rivier, Rivier J, Howard L. Judd, H L Judd, Judd HL
The Journal of clinical endocrinology and metabolism · 1982 · vol. 54(5) , pp. 1081–1083 · doi:10.1210/jcem-54-5-1081 · PMID:6801075 · W2086926841
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This study found that a long-acting GnRH agonist significantly suppressed estrogen secretion in women with endometriosis, mimicking the hormonal profile of oophorectomized individuals and suggesting a new treatment approach.

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Abstract

Five women with endometriosis were given a daily dose of a potent long-acting GnRH agonist, D-Trp6-Pro9-Net-LHRH (GnRH-A) for 28 days in an attempt to suppress ovarian estrogen secretion. The mean level of estradiol (E2) during sampling over 24 hours decreased (P less than 0.01) from 62 +/- 11 to 10 +/- 1 pg/ml at the end of treatment. Mean concentrations of androstenedione, testosterone, estrone and E2 on day 28 of therapy were similar to those measured in oophorectomized women. The level of FSH was decreased (P less than 0.001) during GnRH-a, whereas that of LH was significantly (P less than 0.001) increased, suggesting differing intracellular control mechanisms for release of the two gonadotropins. Desensitization of the pituitary was demonstrated at the end of treatment by a complete lack of acute response of FSH or LH to the daily dose of GnRH-a. "Medical oophorectomy" provides a new approach to the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Ovary Triptorelin Pamoate Triptorelin Pamoate Triptorelin Pamoate Endometriosis Endometriosis Estradiol Estradiol Estradiol Estrone Estrone Estrone Female Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Gonadotropin-Releasing Hormone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (50)

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