The current place of progestins in the treatment of endometriosis

Karl-Werner Schweppe

doi:10.1586/eog.11.71

The current place of progestins in the treatment of endometriosis

Karl-Werner Schweppe

In: Expert Review of Obstetrics & Gynecology · 2012 · vol. 7(2) , pp. 141–148 · doi:10.1586/eog.11.71 · W2015700535

article OA: closed CC0 ⤵ 9 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review discusses the current role of progestins in managing endometriosis, detailing their mechanisms of action, efficacy, and adverse effects.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Karl-Werner Schweppeaa Department of Obstetrics and Gynecology, Ammerland Clinic GmbH, Germany and Ammerland Clinic GmbH, Academic Teaching Hospital of the University of Göttingen, Lange Strasse 28/D-26655 Westerstede, Germany.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (53)

A 3-year follow-up of women with endometriosis and pelvic pain users of the levonorgestrel-releasing intrauterine system via openalex
A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex
A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study via openalex
Aromatase and other steroidogenic genes in endometriosis: translational aspects via openalex
Behandlung der Endometriose mit Dienogest — Einfluß auf den Rezeptorstatus im Endometrium und vergleichende Bindungsstudien via openalex
Changes in quality of life after hormonal treatment of endometriosis via openalex
Changes in quality of life after hormonal treatment of endometriosis via openalex
Comparative Pharmacology of Newer Progestogens via openalex
Conservative Treatment of Endometriosis via openalex
Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis via openalex
Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex
Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex
Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex
Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
DYDROGESTERONE AND ENDOMETRIOSIS via openalex
Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model via openalex
Effects of Progestin-Induced Pseudopregnancy on Endometriosis: Clinical and Microscopic Studies via openalex
Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study via openalex
Endometriosis treated with lynestrenol. via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial via openalex
MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex
Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery via openalex
Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex
Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision via openalex
Progestagens and anti-progestagens for pain associated with endometriosis via openalex
Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex
Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex
Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex
Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex
Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex
Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex
[Surgical treatment of endometriosis and long-term therapy with lynestrenol]. via openalex
The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex
The place of dydrogesterone in the treatment of endometriosis and adenomyosis via openalex
Treatment of Primary Dysmenorrhea via openalex
Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex
Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis via openalex
W2402350390 via openalex
W2415555521 via openalex
W2003244697 via openalex
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W1929676842 via openalex
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W4285719527 via openalex
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W2323757858 via openalex

Cited by (9)

Source provenance

openalex: last seen: 2026-06-04T00:00:01.174412+00:00

License: CC0 · commercial use OK

[1] A 3-year follow-up of women with endometriosis and pelvic pain users of the levonorgestrel-releasing intrauterine system via openalex

[2] A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex

[3] A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study via openalex

[4] Aromatase and other steroidogenic genes in endometriosis: translational aspects via openalex

[5] Behandlung der Endometriose mit Dienogest — Einfluß auf den Rezeptorstatus im Endometrium und vergleichende Bindungsstudien via openalex

[6] Changes in quality of life after hormonal treatment of endometriosis via openalex

[7] Changes in quality of life after hormonal treatment of endometriosis via openalex

[8] Comparative Pharmacology of Newer Progestogens via openalex

[9] Conservative Treatment of Endometriosis via openalex

[10] Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis via openalex

[11] Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex

[12] Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex

[13] Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex

[14] Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex

[15] DYDROGESTERONE AND ENDOMETRIOSIS via openalex

[16] Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model via openalex

[17] Effects of Progestin-Induced Pseudopregnancy on Endometriosis: Clinical and Microscopic Studies via openalex

[18] Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study via openalex

[19] Endometriosis treated with lynestrenol. via openalex

[20] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[21] Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial via openalex

[22] MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex

[23] Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex

[24] Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery via openalex

[25] Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex

[26] Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision via openalex

[27] Progestagens and anti-progestagens for pain associated with endometriosis via openalex

[28] Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex

[29] Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex

[30] Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex

[31] Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex

[32] Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[33] Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[34] [Surgical treatment of endometriosis and long-term therapy with lynestrenol]. via openalex

[35] The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex

[36] The place of dydrogesterone in the treatment of endometriosis and adenomyosis via openalex

[37] Treatment of Primary Dysmenorrhea via openalex

[38] Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex

[39] Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis via openalex

[40] W2402350390 via openalex

[41] W2415555521 via openalex

[42] W2003244697 via openalex

[43] W1981756718 via openalex

[44] W2469310051 via openalex

[45] W1929676842 via openalex

[46] W2131027406 via openalex

[47] W4285719527 via openalex

[48] W2123134517 via openalex

[49] W2101417341 via openalex

[50] W2157853773 via openalex

[51] W2030241225 via openalex

[52] W214103652 via openalex

[53] W2323757858 via openalex