Recurrent endometrioma and ovarian reserve: biological connection or surgical paradox?

Edgardo Somigliana, Laura Benaglia, Paolo Vercellini, Alessio Paffoni, Guido Ragni, G. Ragni, Ragni G, Luigi Fedele
American journal of obstetrics and gynecology · 2011 · vol. 204(6) , pp. 529.e1–529.e5 · doi:10.1016/j.ajog.2011.01.053 · PMID:21419388 · W2077237431
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This paper explores the potential biological link between recurrent endometriomas and ovarian reserve, questioning whether surgical interventions might paradoxically contribute to recurrent disease.

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Abstract

OBJECTIVE: Cumulative evidence supports the view that ovarian endometriomas originate from ovulatory events and that the ovarian reserve is reduced following surgery. On these bases, we have hypothesized that the risk of recurrence may be related to the residual ovarian reserve of the operated ovary. STUDY DESIGN: We retrospectively selected 45 women scheduled for in vitro fertilization who previously underwent surgical excision of monolateral endometriomas and compared ovarian responsiveness in those who did (n = 24) and did not (n = 21) have a recurrent endometrioma. RESULTS: In the intact ovaries, the mean ± SD number of codominant follicles in women with and without recurrences was 3.5 ± 1.7 and 3.7 ± 2.2, respectively (P = NS). In the affected ovaries, the mean ± SD number of follicles in gonads with and without recurrences was 2.5 ± 2.3 and 1.1 ± 1.5, respectively (P < .05). CONCLUSION: Ovarian responsiveness is higher in gonads that developed recurrent endometriomas.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Ovulation Ovulation Adult Adult Endometriosis Endometriosis Female Female Humans Humans Ovarian Diseases Ovarian Diseases Recurrence Recurrence Retrospective Studies Retrospective Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (29)

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