Endometriosis

In: Clinical Reproductive Medicine and Surgery · 2017 · pp. 433–446 · doi:10.1007/978-3-319-52210-4_24 · W4238018897
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Endometriosis is a chronic gynecologic disease affecting 10% of the population, with varied presentations and few conclusive theories on its pathophysiology or associated infertility.

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This paper/chapter overviews endometriosis as a chronic gynecologic disease characterized by varied symptoms, physical findings, and treatment approaches, noting that about 10% of the population is affected and that prevalence is higher among women with chronic pelvic pain or infertility. It reviews hypotheses for disease predisposition and pathophysiology, including estrogen-driven factors and genetic components, and highlights that there is no conclusive theory explaining its mechanisms or the causes of associated infertility and pain. The chapter summarizes evidence on managing infertility (surgical and medical) and pain, while noting limitations such as the classification schemes being of limited value to clinicians. This paper is centrally about endometriosis — it provides a broad evidence-based review of its symptoms, hypothesized mechanisms, and treatment approaches.

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Abstract

Endometriosis is a chronic gynecologic disease with a pleiotropic symptomatology, physical presentation, and treatment approaches. Ten percent of the population is affected; however, the prevalence in chronic pelvic pain or infertility-stricken women is much higher. Surgical diagnosis is adequate, but the classification scheme is of little value to clinicians. Apart from a genetic component to endometriosis, there are other predisposing factors that are predominately estrogen driven. Several hypotheses exist, but there is no conclusive theory for either the pathophysiology of endometriosis or the mechanisms for attributed infertility and pain. This chapter describes approaches to treating infertility (both surgically and medically) as well as managing pain symptoms. As much as the literature provides, evidence-based studies have been summarized to maximize your treatment approaches to this vexing disease. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations - Chronic pelvic pain: - Pain below the umbilicus that is of at least 6 months’ duration and causes functional disability - Deep endometriosis: - When the endometrial tissue invades deeper than 5 mm - Endometrioma: - Ovarian cyst lined by endometrial tissue and containing thick, brown, tar-like fluid - Endometriosis: - Endometrial cells are found outside the uterus and lead to symptoms such as severe pelvic pain, dysmenorrhea, dyspareunia, and subfertility - Müllerianosis: - Endometrial tissue located at sites outside of the uterus during the embryologic period of organogenesis - Sampson’s theory: - Retrograde menstruum exits through the fallopian tubes into the pelvis and in some women this could eventually lead to the development and establishment of endometriosis - Subfertility: - Reduced fertility over a prolonged period of time

References

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Springer, Cham. https://doi.org/10.1007/978-3-319-52210-4_24 Download citation DOI: https://doi.org/10.1007/978-3-319-52210-4_24 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-52209-8 Online ISBN: 978-3-319-52210-4 eBook Packages: MedicineMedicine (R0)

Keywords

- Bone Mineral Density - Chronic Fatigue Syndrome - Interstitial Cystitis - Chronic Pelvic Pain - Combine Oral Contraceptive These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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endometriosis

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References (31)

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