Recurrent endometrioma and ovarian reserve: biological connection or surgical paradox?

Edgardo Somigliana, Laura Benaglia, Paolo Vercellini, Alessio Paffoni, Guido Ragni, G. Ragni, Ragni G, Luigi Fedele
American journal of obstetrics and gynecology · 2011 · vol. 204(6) , pp. 529.e1–529.e5 · doi:10.1016/j.ajog.2011.01.053 · PMID:21419388 · W2077237431
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This paper explores the potential biological link between recurrent endometriomas and ovarian reserve, questioning whether surgical interventions might paradoxically contribute to recurrent disease.

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Abstract

ObjectiveCumulative evidence supports the view that ovarian endometriomas originate from ovulatory events and that the ovarian reserve is reduced following surgery. On these bases, we have hypothesized that the risk of recurrence may be related to the residual ovarian reserve of the operated ovary.Study designWe retrospectively selected 45 women scheduled for in vitro fertilization who previously underwent surgical excision of monolateral endometriomas and compared ovarian responsiveness in those who did (n = 24) and did not (n = 21) have a recurrent endometrioma.ResultsIn the intact ovaries, the mean ± SD number of codominant follicles in women with and without recurrences was 3.5 ± 1.7 and 3.7 ± 2.2, respectively (P = NS). In the affected ovaries, the mean ± SD number of follicles in gonads with and without recurrences was 2.5 ± 2.3 and 1.1 ± 1.5, respectively (P < .05).ConclusionOvarian responsiveness is higher in gonads that developed recurrent endometriomas.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Ovulation Adult Endometriosis Female Humans Ovarian Diseases Recurrence Retrospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (30)

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