Bacterial infection in endometriosis: a silver-lining for the development of new non-hormonal therapy?

Khaleque Newaz Khan, Dominique de Ziegler, Sun‐Wei Guo
Human Reproduction · 2024 · vol. 39(4) , pp. 623–631 · doi:10.1093/humrep/deae006 · PMID:38300227 · W4391449985
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This paper explores the potential role of bacterial infection, particularly *Fusobacterium*, in endometriosis pathogenesis and shows that antibiotic treatment reduced lesion size in a mouse model, suggesting a new non-hormonal therapeutic avenue.

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Abstract

The pathogenesis of endometriosis is a hotly debated topic, yet still cloaked in multiple layers of hypothetical theories. A recent report raises the possibility that bacterial infection, especially those of the genus Fusobacterium, may be the cause of endometriosis, at least in certain women. More importantly, the demonstration that treatment with broad-spectrum antibiotics significantly reduced the size of lesions in a mouse endometriosis model rekindles the hope for new non-hormonal treatments. The development of new therapies has been plagued by strings of unsuccessful clinical trials over the last two decades. Is this antibiotic therapy, a silver lining for the research and development of non-hormonal drugs for endometriosis?

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Condition tags

endometriosis

MeSH descriptors

Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections Bacterial Infections

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (77)

Cited by (5)

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