Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: a prospective study

Zhang X, Xin Zhang, Min Zou, Zou M, Cai Zhang, Zhang C, Jia He, He J, Mao S, Shihua Mao, Wu Q, Qingrong Wu, He M, Min He, Wang J, Jian Wang, Ruitao Zhang, Zhang R, Lian Zhang, Zhang L
European journal of radiology · 2014 · vol. 83(9) , pp. 1607–1611 · doi:10.1016/j.ejrad.2014.05.008 · PMID:24951357 · W1975338906
RCT OA: closed CC0 ⤵ 13 in-corpus citations
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This prospective study investigated the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation of adenomyosis.

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Abstract

OBJECTIVE: To investigate the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis. MATERIALS AND METHODS: Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment. During HIFU treatment, 80 units of oxytocin was added in 500ml of 0.9% normal saline running at the rate of 2ml/min (0.32U/min) in the oxytocin group, while 0.9% normal saline was used in the control group. Both patients and HIFU operators were blinded to oxytocin or saline application. Treatment results, adverse effects were compared. RESULTS: When using oxytocin, the non-perfused volume (NPV) ratio was 80.7±11.6%, the energy-efficiency factor (EEF) was 8.1±9.9J/mm(3), and the sonication time required to ablate 1cm(3) was 30.0±36.0s/cm(3). When not using oxytocin, the non-perfused volume ratio was 70.8±16.7%, the EEF was 15.8±19.6J/mm(3), and the sonication time required to ablate 1cm(3) was 58.2±72.7S/cm(3). Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1cm(3) between the two groups was observed. No oxytocin related adverse effects occurred. CONCLUSION: Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU, safely enhance the treatment efficiency.

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MeSH descriptors

Adenomyosis High-Intensity Focused Ultrasound Ablation Oxytocics Oxytocin Adenomyosis Adenomyosis Adult Adult Female Female Follow-Up Studies Follow-Up Studies Gadolinium Gadolinium High-Intensity Focused Ultrasound Ablation High-Intensity Focused Ultrasound Ablation Humans Humans Image Enhancement Image Enhancement

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