The effect of danazol on menorrhagia, coagulation mechanisms, haematological indices and body weight
Non-randomised trial
OA: closed
CC0
⤵ 27 in-corpus citations
AI-generated summary
Danazol treatment significantly reduced menstrual blood loss and increased hemoglobin levels in patients with menorrhagia, with benefits persisting three months after cessation.
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Abstract
Eighteen patients with objective evidence of menorrhagia (more than 80 ml menstrual blood loss) were treated with danazol for twelve weeks. Danazol significantly reduced the menstrual blood loss from 231 +/- 39 ml (mean +/- SEM) to 135 +/- 33 ml in the first treatment month and the mean loss thereafter was only 21 ml and 3 ml for the second and third months respectively. A rapid increase in haemoglobin level and a reduction in the number of days of bleeding were also observed on danazol treatment. No important effect on the coagulation profile was observed during the period of study. Three months after stopping danazol, menstrual blood loss (103 +/- 27 ml) was still significantly less than the pre-treatment loss.
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Cited by (24)
- Danazol 2022
- Medical management of heavy menstrual bleeding: a comprehensive review of the literature 2015
- Physicochemical, in silico and in vivo evaluation of a danazol-beta-cyclodextrin complex 2007
- Danazol-beta-cyclodextrin binary system: a potential application in emergency contraception by the oral route 2007
- Benefits and risks of pharmacological agents used for the treatment of menorrhagia 2004
- Medical management of dysfunctional uterine bleeding 2003
- Danazol for heavy menstrual bleeding 2002
- Medical management of dysfunctional uterine bleeding 1999
- Hysteroscopic endometrial ablation 1995
- A comparative study of danazol, a regimen of decreasing doses of danazol, and norethindrone in the treatment of objectively proven unexplained menorrhagia 1993
- Lipoprotein Lp(a) levels are reduced by danazol, an anabolic steroid 1992
- Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate 1990
- Danazol in menorrhagia: a double blind placebo controlled trial 1987
- Erythrocytosis induced by danazol in an anephric patient 1987
- Treatment of dysfunctional uterine bleeding with danazol 1985
- Hot flashes in postmenopausal women ameliorated by danazol 1985
- Danazol as an ovulation inhibitor prior to tubal surgery 1984
- The interaction of human endometrial and myometrial steroid receptors with danazol 1983
- Danazol 1982
- An interaction between danazol and warfarin. Case report 1981
- Danazol treatment and platelet function 1980
- Effect of danazol on serum gonadotrophins and steroid hormone concentrations in women with menorrhagia 1980
- Danazol suppresses luteal function in vitro and in vivo 1980
- Reduction of menstrual blood loss by danazol in unexplained menorrhagia: lack of effect of placebo 1980
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:58:54.395363+00:00
- unpaywall
- last seen: 2026-10-12T06:33:14.382917+00:00
License: CC0
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