Danazol as an ovulation inhibitor prior to tubal surgery

L Tesquier, J Henry‐Suchet, T Loysel, Y Robert, V. Loffredo
In: Diagnosis and Management of Tubo-Uterine Factors in Infertility · 1984 · pp. 203–205 · doi:10.1007/978-94-011-7621-7_40 · W2278433861
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This study aimed to demonstrate danazol's usefulness in blocking ovulation before and after tubal plastic surgery to facilitate the procedure and prevent postoperative adhesions.

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This paper describes the rationale for using danazol as an ovulation inhibitor before and after tubal plastic surgery, to facilitate the surgical procedure and to reduce postoperative adhesions involving the tube and corpus luteum. The authors note that ovarian tissue becomes smaller and harder with less tendency to bleed, and they report that a second-look laparoscopy 8 days after surgery confirmed reduced adhesion formation, referencing earlier published work. A limitation explicitly acknowledged in the text is that alternative hormonal approaches (oestroprogestagens or norethisterone) might achieve similar results but were not acceptable due to an unacceptable thromboembolic risk in the surgical context. Relevance to endometriosis: the study rationale is linked to prior interim reports of danazol use for endometriosis in the references, though the paper’s main focus is ovulation inhibition around tubal surgery rather than endometriosis or adenomyosis outcomes.

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Abstract

The aim of the present study was to demonstrate the usefulness of blocking ovulation before and after tubal plastic surgery. J. Henry-Suchetl, then Buttram2, have described the use of such a pre- and postoperative treatment for two reasons: - (1) The surgical act is facilitated: ovariolysis can be done in better conditions, in particular when adhesions are dense and extensive. Ovaries become small and hard with a reduced tendency to bleed. - (2) It prevents postoperative adhesion of the tube to a recent corpus luteum and reduces formation after ovarian surgery of new adhesions. This has been confirmed by a second-look laparoscopy on 8 days postoperatively and has been published earlier3. Oestroprogestagens or norethisterone could reach an equivalent result but the thromboembolic risk is unacceptable in surgery. Similar content being viewed by others

References

Henry-Suchet, J. and Loffredo, V. (1981). Compared results between two series of terminal tuboplasties. In GAM Lausanne. p. 521. Revue médicale de la Suisse Romande. Buttram, V. C., Belue, J. B. and Reiter, R. (1982). Interim report of a study of danazol for the treatment of endometriosis. Fertil. Steril., 37, 478 Henry-Suchet, J. and Loffredo, V. (1982). Techniques d’évaluation des résultats de la microchirurgie tubaire. In Cornier, E. (ed.) Techniques Microchirurgicales de la Stérilité. p. 169. ( Paris: Masson ) Chimbira, T.H., Cope, E., Anderson, B. M. and Bolton, F. G. (1979). The effect of danazol on menorrhagia, coagulation mechanism, haematological indices and body weight. Br. J. Obstet. Gynaecol., 86, 46 Rakoff, A. E. (1976). Side effects of danazol therapy. In Greenblatt, R. B. (eds.) Recent Advances in Endometriosis. pp. 108–15. ( Princeton, N.J.: Excerpta Medica ) Editor information Editors and Affiliations Rights and permissions Copyright information © 1984 MTP Press Limited About this chapter Cite this chapter Tesquier, L., Henry-Suchet, J., Loysel, T., Robert, Y., Loffredo, V. (1984). Danazol as an ovulation inhibitor prior to tubal surgery. In: Harrison, R.F., Bonnar, J., Thompson, W. (eds) Diagnosis and Management of Tubo-Uterine Factors in Infertility. Studies in Fertility and Sterility, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7621-7_40 Download citation DOI: https://doi.org/10.1007/978-94-011-7621-7_40 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-011-7623-1 Online ISBN: 978-94-011-7621-7 eBook Packages: Springer Book Archive

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