Conservative treatment of deep infiltrating endometriosis: review of existing options

Maria Szubert, Magdalena Ziętara, Ziętara M, Jacek Suzin, Suzin J
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 34(1) , pp. 10–14 · doi:10.1080/09513590.2017.1381837 · PMID:28952821 · W2757037178
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This review of conservative treatment options for deep infiltrating endometriosis highlights hormonal therapy as first-line, with GnRH analogs, danazol, or surgery as second-line options depending on expert opinion and patient response.

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Abstract

Endometriosis with its estimated incidence rate of ∼7-10% of women of reproductive age is a disease with the wide spectrum of symptoms depending on form and localization of endometrial foci. One clinical form of endometriosis is deep infiltrating endometriosis (DIE), most difficult to manage and generating a lot of direct and indirect treatment costs. We search the literature from PubMed database to establish the role of conservative treatment of DIE. Randomised controlled trials are lacking but in experts opinion hormonal treatment should be the first-line treatment in DIE. After evaluation of pain or other symptoms, second-line therapy with GnRH analogs or danazol should be offered or minimally invasive surgery. Consensus is not made whether surgery is the best therapeutic treatment for affected patients. Strong depending on surgeon's experience conservative surgery should be offered if the total excision of DIE foci is possible, which is essential for a successful outcome. If available treatment options do not release pain associated with DIE, experimental treatment in clinical trials should be discussed with patients.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Conservative Treatment Endometriosis Adult Adult Conservative Treatment Conservative Treatment Contraceptives, Oral, Combined Contraceptives, Oral, Combined Contraceptives, Oral, Combined Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (51)

Cited by (7)

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License: CC0 · commercial use OK