Intérêt actuel des selective progesterone receptor modulators (SPRM) dans l’endométriose

P Merviel, Philippe Merviel, E Lourdel, Lourdel E, S Sanguin, Sanguin S, O Gagneur, Gagneur O, R Cabry, Cabry R, A Nasreddine, Nasreddine A
Gynecologie, obstetrique & fertilite · 2013 · vol. 41(9) , pp. 524–528 · doi:10.1016/j.gyobfe.2013.07.016 · PMID:23972920 · W2074867696
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This review explores the current interest in selective progesterone receptor modulators (SPRMs) for treating endometriosis.

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Abstract

The SPRM (selective progesterone receptor modulators) are agonists and/or antagonists of progesterone receptor. They are responsible for anovulation, amenorrhea and a lower prostaglandin levels, which leads to an improvement in pain and regression of lesions in endometriosis. On the endometrium, a particular aspect, the progesterone receptor modulator-associated endometrial changes (PAEC), raises additional studies to verify its harmlessness. However, due to the lack of hypoestrogenism and metabolic effects with these drugs, it is very likely that the SPRM will in the near future an important place in the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Receptors, Progesterone Receptors, Progesterone Amenorrhea Animals Anovulation Endometriosis Endometrium Endometrium Female Hormone Antagonists Humans Norethindrone Norethindrone Norpregnadienes Norpregnadienes Progesterone Progesterone Prostaglandins Prostaglandins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

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