Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature

Alessandro Pontis; Pontis Alessandro; Nappi Luigi; Luigi Nappi; Felice Sorrentino; Sorrentino Felice; Paoletti Anna Maria; Melis Gian Benedetto; Angioni Stefano; Stefano Angioni

doi:10.1007/s00404-017-4328-6

Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature

Alessandro Pontis, Pontis Alessandro, Nappi Luigi, Luigi Nappi, Felice Sorrentino, Sorrentino Felice, Paoletti Anna Maria, Melis Gian Benedetto, Angioni Stefano, Stefano Angioni

Archives of gynecology and obstetrics · 2017 · vol. 295(4) , pp. 827–832 · doi:10.1007/s00404-017-4328-6 · PMID:28255765 · W2593412351

review OA: closed CC0 ⤵ 18 in-corpus citations

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Hormone Antagonists Hydrocarbons, Fluorinated Pyrimidines Adult Endometriosis Endometriosis Estradiol Estradiol Female Gonadotropin-Releasing Hormone Gonadotropins Gonadotropins Hormone Antagonists Humans Hydrocarbons, Fluorinated Pain Pain Pain

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References (31)

Cited by (18)

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[1] Adenomyosis: a systematic review of medical treatment via openalex

[2] Alexithymia in Women with Deep Endometriosis? A Pilot Study via openalex

[3] Anti-Mullerian hormone trend evaluation after laparoscopic surgery of monolateral endometrioma using a new dual wavelengths laser system (DWLS) for hemostasis via openalex

[4] Can postoperative GnRH agonist treatment prevent endometriosis recurrence? A meta-analysis via openalex

[5] Characterization of endometriosis-associated immune cell infiltrates (EMaICI) via openalex

[6] Clinical outcomes associated with surgical treatment of endometrioma coupled with resection of the posterior broad ligament via openalex

[7] Diagnostic value of transvaginal 'tenderness-guided' ultrasonography for the prediction of location of deep endometriosis via openalex

[8] Elagolix, an Oral GnRH Antagonist for Endometriosis-Associated Pain: A Randomized Controlled Study via openalex

[9] Elagolix, an oral gonadotropin-releasing hormone antagonist, for the management of endometriosis-associated pain: safety and efficacy results from two double-blind, randomized, placebo-controlled studies via openalex

[10] Elagolix, a Novel, Orally Bioavailable GnRH Antagonist under Investigation for the Treatment of Endometriosis-Related Pain via openalex

[11] Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study via openalex

[12] Endometrial expression of estrogen receptor β and its splice variants in patients with and without endometriosis via openalex

[13] Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis via openalex

[14] Focusing on surgery results in infertile patients with deep endometriosis via openalex

[15] New adverse obstetrics outcomes associated with endometriosis: a retrospective cohort study via openalex

[16] New trends of progestins treatment of endometriosis via openalex

[17] Overview of elagolix for the treatment of endometriosis via openalex

[18] Progestins for Symptomatic Endometriosis: Results of Clinical Studies via openalex

[19] Sexual Function in Women with Deep Endometriosis: Correlation with Quality of Life, Intensity of Pain, Depression, Anxiety, and Body Image via openalex

[20] Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix via openalex

[21] The effect of elagolix on bone mineral density: safety results from two randomized, placebo-controlled studies in women with endometriosis-associated pain via openalex

[22] The effect of elagolix on the endometrium: safety results from two randomized, placebo-controlled studies in women with endometriosis-associated pain via openalex

[23] The impact of elagolix on quality of life in women with endometriosis-associated pain: results from two randomized, placebo-controlled studies using the endometriosis health profile questionnaire via openalex

[24] The role of ovarian fossa evaluation in patients with ovarian endometriosis via openalex

[25] Umbilical endometriosis primary site without pelvic endometriosis and previous surgery: a case report via openalex

[26] Use of elagolix for the management of endometriosis-associated pain: secondary efficacy results from two randomized, placebo-controlled studies via openalex

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