A tumor necrosis factor-α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid

Yi‐Jen Chen, Yi-Jen Chen, Chen YJ, Hua-Hsi Wu, Wu HH, Liau WT, Wan-Ting Liau, Tsai CY, Chang‐Youh Tsai, Chang-Youh Tsai, Hsiao‐Wen Tsai, Tsai HW, Hsiao-Wen Tsai, Chao KC, Kuan-Chong Chao, Yen-Jen Sung, Sung YJ, Hsin-Yang Li, Li HY
Fertility and sterility · 2013 · vol. 100(5) , pp. 1476–1485.e5 · doi:10.1016/j.fertnstert.2013.07.1985 · PMID:24012198 · W2014980855
Lab / animal OA: closed CC0 ⤵ 15 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated how a TNF-α inhibitor impacts the embryotoxic effects of peritoneal fluid from patients with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine whether a tumor necrosis factor-α (TNF-α) inhibitor can reduce the embryotoxicity of the peritoneal fluid (PF) of women with endometriosis. DESIGN: Experimental clinical study. SETTING: University hospital. PATIENT(S): Twelve women with chocolate cysts and 12 control women without endometriosis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): We collected the PF from patients with chocolate cysts (CH-PF) and patients without endometriosis (N-PF) during laparoscopic surgery. For the in vitro studies, development and apoptosis were evaluated in two-cell stage mouse embryos after incubation with CH-PF and N-PF, with or without a TNF-α inhibitor. RESULT(S): We found that CH-PF significantly decreased the rate of blastocyst development and increased the percentage of apoptotic cells in the embryos. Cytokine assays showed that the concentrations of several cytokines, including TNF-α, were higher in embryos incubated with CH-PF than in those incubated with N-PF. Furthermore, the treatment of embryos with TNF-α retarded development and induced apoptosis. Important, adalimumab, a TNF-α inhibitor, effectively abrogated the embryotoxicity that was induced by CH-PF. CONCLUSION(S): These data collectively highlight the crucial role of TNF-α in CH-PF-induced embryotoxicity and suggest that TNF-α inhibitors may be potential therapeutic agents for treating endometriosis-induced infertility.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Antibodies, Monoclonal, Humanized Ascitic Fluid Blastocyst Endometriosis Ovarian Cysts Tumor Necrosis Factor-alpha Adalimumab Adalimumab Adult Adult Animals Animals Antibodies, Monoclonal, Humanized Antibodies, Monoclonal, Humanized Apoptosis Apoptosis Apoptosis Ascitic Fluid Ascitic Fluid Blastocyst

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (51)

Cited by (15)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:12:29.265612+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK