Increase in the number of integrinbeta1-immunoreactive monocyte-lineage cells in experimentally-induced adenomyosis in mice

Kawahara R, Ryouka Kawahara, Manabu Matsuda, Matsuda M, Mori T, Takao Mori
Life sciences · 2003 · vol. 73(7) , pp. 907–916 · doi:10.1016/s0024-3205(03)00350-3 · PMID:12798416 · W1999178573
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This study observed an increased number of monocyte-lineage cells expressing integrin beta 1 in mice experiencing experimentally induced adenomyosis.

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Abstract

Uterine adenomyosis is a disease in which hyperplastic endometrial stroma and glands invade the myometrium. We have previously demonstrated that hyperprolactinemia leads to the development of adenomyosis in mice. In the present study, a subtracted cDNA library was made by suppression subtractive hybridization to find specific genes that are abundantly expressed in the adenomyotic but not normal tissue in mice. A cDNA fragment of integrinbeta1 (ibeta1) was found in the library, and the expression of the gene product was increased in the adenomyotic uteri at mRNA and protein levels. Intense ibeta1-immunoreactivity was localized on a group of cells dispersing throughout the endometrial stroma. The number of ibeta1-immunoreactive (ibeta1-ir) cells was significantly greater in the uteri of mice with adenomyosis than normal mice. The majority of the ibeta1-ir cells expressed CD14-ir signal, a marker for monocyte-lineage cells, whereas an increase in the number of CD14-ir cells was also evident in the adenomyotic uteri, especially in the ectopic endometrial tissue. Thus, the adenomyotic stromal tissue contained numerous monocyte-lineage cells with higher expression levels of ibeta1, one of their products. The relationship between the increased number of monocyte-lineage cells and the hyperplastic proliferation of endometrial tissues was discussed with a view to understanding the progressive mechanism of adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Integrin beta1 Monocytes Uterine Diseases Animals Animals Cell Count Cell Count Cell Lineage Cell Lineage Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometriosis Female Female Gene Library Gene Library

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (7)

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