Differential expression of selected gene products in uterine leiomyomata and adenomyosis

M. G. Levy, Levy M, Mary Levy, Mittal K, Khush Mittal, Luis Chiriboga, Zhang X, Xinmin Zhang, Herman Yee, Yee H, Wei JJ, Jian-Jun Wei
Fertility and sterility · 2007 · vol. 88(1) , pp. 220–223 · doi:10.1016/j.fertnstert.2006.11.104 · PMID:17296180 · W1991376654
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⚙ AI-generated summary by claude@2026-07, 2026-07-07 ⓘ

Immunohistochemistry revealed significant differences in the expression of ERα, PR-A, RXRα, IGF-II, IGFI-Rβ, PDGF, EGFR, and BCL-2 between adenomyosis and uterine leiomyomata tissues.

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Abstract

Gene products estrogen receptor alpha, progesterone receptor-A, retinoid X receptor alpha, insulin-like growth factor-II, insulin-like growth factor I receptor beta, platelet-derived growth factor, epithelial growth factor receptor, and BCL-2 were examined by immunohistochemistry with the aid of a tissue microarray from 46 hysterectomies with adenomyosis and leiomyomata. With appropriate internal controls, there were significant differences in gene expression between adenomyosis and leiomyomata.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometriosis Gene Expression Profiling Leiomyomatosis Leiomyomatosis Adult Endometriosis Female Genetic Markers Genetic Markers Humans Immunohistochemistry Leiomyomatosis Middle Aged

Citation neighborhood

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References (12)

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