Dioxin-like compounds and endometriosis: a study on Italian and Belgian women of reproductive age

Elena De Felip, De Felip E, Maria Grazia Porpora, Alessandro Di Domenico, di Domenico A, M. Cardelli, Anna Maria Ingelido, Massimo Cardelli, Ermelando V. Cosmi, Cardelli M, Jacques Donnez, Cosmi EV, Donnez J
Toxicology letters · 2004 · vol. 150(2) , pp. 203–209 · doi:10.1016/j.toxlet.2004.01.008 · PMID:15093675 · W2093943696
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This study investigated the association between dioxin-like compound exposure and endometriosis in Italian and Belgian women of reproductive age.

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Abstract

Compounds with dioxin-like toxicity are suspected to adversely affect human reproduction even at current background exposures. Endometriosis, a gynecological disorder often associated with infertility, has been hypothesized to be linked to dioxins and similar chemicals, a hypothesis supported by the outcome of experimental studies on animal models. Endometriosis severity and incidence in Belgium is one of the highest of the world: in this country, the general population exposure to dioxin-like compounds has been, on average, higher than in most industrialized countries. Here we show the results of a pilot case-control study carried out on 22 Italian and 18 Belgian women of reproductive age, with and without endometriosis. No significant differences were found in dioxin-like compound body burdens between cases and controls on a country basis, whereas the body burdens of the Italian women resulted to be significantly lower than that of the Belgian. In particular, total TEQs in Italian and Belgian women without endometriosis were respectively 18 and 45 pg WHO-TE/g lb.

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Condition tags

endometriosis

MeSH descriptors

Dioxins Endometriosis Environmental Exposure Environmental Pollutants Adolescent Adolescent Adult Adult Belgium Belgium Belgium Body Burden Body Burden Case-Control Studies Case-Control Studies Dioxins Dioxins Dioxins Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (37)

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