Environmental dioxin compounds as the cause of endometriosis and other diseases

Simsa P, Péter Simsa, Zsuzsanna Éva Járási, Zsuzsanna Eva Járási, Járási ZE, Fülöp V, Vilmos Fülöp
Orvosi hetilap · 2007 · vol. 148(37) , pp. 1745–1750 · doi:10.1556/oh.2007.28172 · PMID:17827083 · W1920554011
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This paper argues that human genetic resistance to dioxins suggests their concentrations in the population are too low to cause endometriosis, contradicting some conflicting experimental findings.

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Abstract

There has been much debate of late about whether or not dioxin, an industrial toxin, could be a causative agent in the onset of endometriosis, a gynaecological disease associated with infertility and pain. Studies found either no difference in serum dioxin concentrations when cases were compared to controls or a non-significant increase, or reached low statistical power. The introductory results on Rhesus monkey contradict with the observations on mice fed with dioxin and oestrogen simultaneously. Genetic comparison shows that human belongs to the dioxin resistant races so dioxin concentrations measured in the population could not cause disease especially not an oestrogen dependent one, like endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Dioxins Endometriosis Environmental Exposure Environmental Pollutants Animals Dioxins Endometriosis Environmental Exposure Environmental Pollutants Female Humans Macaca mulatta Mice

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