Brain-derived neurotrophic factor in plasma of women with endometriosis

Andrea Giannini, Fiorella Bucci, Stefano Luisi, Vito Cela, Nicola Pluchino, Sara Merlini, Elena Casarosa, Marinella Russo, Alessandra Cubeddu, Diana Daino, Paolo Giovanni Artini, Andrea Riccardo Genazzani
2010 · vol. 2(3) , pp. 144–150 · doi:10.5301/je.2010.5779 · W1892985728
Observational OA: closed CC0 ⤵ 11 in-corpus citations
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Plasma levels of brain-derived neurotrophic factor (BDNF) were significantly higher in women with endometriosis compared to controls and decreased after surgery, while follicular fluid BDNF was lower in endometriosis patients.

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Abstract

Purpose: Endometriosis is one of the most common benign gynecological diseases affecting women of reproductive age; it is characterized by the presence and growth of ectopic endometrial tissue outside the endometrial cavity. This complex disease is frequently associated with infertility and pelvic pain. Given the relationship and the apparent importance of the role that neurotrophins play in the reproductive system, and in particular brain-derived neurotrophic factor (BDNF) which is involved in both the central and peripheral pain pathways, we were interested in determining whether the presence of endometriosis is associated and correlated with plasma and follicular fluid variation of BDNF. Methods: We determined BDNF level in plasma and in follicular fluid from infertile women with endometriosis and fertile women without the disease. Results: BDNF plasma levels were significantly higher in endometriotic patients than in control women (p<0.001). After surgery this level decreased significantly (p<0.001), ranging within the values of control women in follicular phase. In follicular fluid, BDNF values were significantly lower in infertile women for endometriosis than in infertile women for male factors (p<0.001). Conclusion: These data raise the possibility that neuroinflammatory reactions in endometriosis could have a neuroprotective effect and support the hypothesis that BDNF represents an important link in the networks of human homeostasis, thus providing an early marker for patients affected by endometriosis. Moreover, low BDNF levels in follicular fluid may reflect an altered ovary production and may be a marker of poor oocyte quality and poor fertility in women suffering from endometriosis.

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Condition tags

endometriosisinfertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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