Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis

Cinzia Di Pietro, Ettore Cicinelli, Maria Rosa Guglielmino, Maria R Guglielmino, Marco Ragusa, Marco Farina, Marco Palumbo, Marco A Palumbo, Antonio Cianci
American journal of reproductive immunology (New York, N.Y. : 1989) · 2013 · vol. 69(5) , pp. 509–517 · doi:10.1111/aji.12076 · PMID:23351011 · W2056656419
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This study found that infertile women with chronic endometritis exhibit altered endometrial gene expression of cytokines, growth factors, and apoptotic proteins compared to controls.

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Abstract

PROBLEM: Chronic endometritis (CE) is a poorly investigated and probably underestimated pathology, which may cause abnormal uterine bleeding (AUB), pain, and reproductive failures. Due to undefined symptoms and the normal presence of leukocytes in the endometrial mucosa, diagnosis may be missed. Fluid hysteroscopy is a reliable technique for diagnosing this pathology. Few data exist on the biochemical and paracrine alterations that occur in the endometrium of women diagnosed with CE. The aim of the study was to find molecular modification in endometrium related to CE. METHOD OF STUDY: Sixteen women with hysteroscopic and histological diagnosis of CE and 10 healthy women as controls were enrolled. We compared the endometrial expression profile of 25 genes encoding proteins involved in the inflammatory response, proliferation, and apoptosis in endometrium during implantation window, using high-throughput real-time RT-PCR. RESULTS: In women with CE, the endometrial expression of some genes was significantly altered. In particular, IGFBP1, BCL2, and BAX were up-regulated, while IL11, CCL4, IGF1, and CASP8 were down-regulated. CONCLUSION: The altered gene endometrial expression may explain the impaired endometrial receptivity and the finding of endometrial hyperplastic lesions in women affected by CE.

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Condition tags

disambig:endometritis

MeSH descriptors

Endometritis Endometrium Infertility, Female Adult Apoptosis Apoptosis bcl-2-Associated X Protein bcl-2-Associated X Protein bcl-2-Associated X Protein Caspase 8 Caspase 8 Caspase 8 Chemokine CCL4 Chemokine CCL4 Chemokine CCL4 Chronic Disease Embryo Implantation, Delayed Endometritis Endometritis Endometritis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (29)

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