Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder

Xinmei Zhang, Zhang X, Hong Xu, Xu H, Jun Lin, Lin J, Qian Y, Yuli Qian, Lin Deng, Deng L
BJOG: An International Journal of Obstetrics & Gynaecology · 2005 · vol. 112(8) , pp. 1153–1155 · doi:10.1111/j.1471-0528.2005.00639.x · PMID:16045534 · W2060196904
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This study found higher peritoneal fluid interleukin-17 in patients with minimal/mild endometriosis and when endometriosis coexists with infertility, suggesting IL-17's role in early disease and associated infertility.

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Abstract

This prospective study aimed to determine whether patients with endometriosis are having different level of interlukin-17 (IL-17) in peritoneal fluid when compared with patients without endometriosis. The patients with minimal/mild endometriosis had a significantly higher level of IL-17 in peritoneal fluid compared with those with moderate/severe endometriosis or without endometriosis. The concentration of IL-17 in peritoneal fluid was significantly higher when endometriosis and infertility coexist. However, the concentration of IL-17 in peritoneal fluid did not correlate with the phase of the menstrual cycle in the patients with or without endometriosis. Our study suggested that IL-17 might play an important role in the pathogenesis of early endometriosis and endometriosis-associated infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Infertility, Female Interleukin-17 Abdominal Pain Abdominal Pain Abdominal Pain Adult Adult Ascitic Fluid Ascitic Fluid Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (7)

Cited by (50)

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