Preliminary report on the use of danazol in the treatment of endometrial adenomatous hyperplasia
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⤵ 8 in-corpus citations
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Danazol treatment for 3 months resulted in symptom resolution and regression of adenomatous hyperplasia in five patients, suggesting its potential for treating this condition.
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Abstract
Since the authors recently reported that danazol inhibits the growth of human endometrial cancer cells in vitro, a clinical trial was initiated to examine whether danazol can regress adenomatous hyperplasia, a precursor of endometrial adenocarcinoma. Danazol was used for 3 months in the treatment of five patients with a history of hypermenorrhea and irregular uterine bleeding. Within a 9-month follow-up period, all patients were symptom-free, and none of the specimens obtained by endometrial biopsy showed the presence of adenomatous hyperplasia. These findings suggest that danazol has a potential application in the treatment of patients with endometrial adenomatous hyperplasia. A possible mechanism of action of the compound in adenomatous hyperplasia is also discussed.
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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (8)
- Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro via openalex
- Danazol has progestin-like actions on the human endometrium via openalex
- Growth inhibition by danazol in a human endometrial cancer cell line with estrogen-independent progesterone receptors via openalex
- Preliminary report on postmenopausal endometrial hyperplasia treatment with Danazol: histological and endocrinological aspects via openalex
- Short-term effects of danazol and medroxyprogesterone acetate on cytosol and nuclear estrogen and progestin receptors, 17 beta-hydroxysteroid dehydrogenase activity, histopathology, and ultrastructure of human endometrial adenocarcinoma via openalex
- Short-term effects of danazol on endometrial histology via openalex
- doi:10.1002/1097-0142(19880401)61:7<1312::aid-cncr2820610706>3.0.co;2-k via openalex
- doi:10.1016/0002-9378(81)90611-6 via openalex
Cited by (8)
- Molecular profiling of human endometrium and endometriosis 2010
- Preventive effects of danazol on endometrial carcinogenesis in mice 2000
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Postmenopausal endometrial hyperplasia: role of danazol therapy 1994
- Suppression of the development of uterine adenomyosis by danazol treatment in mice 1992
- Endometrial effects of danazol in perimenopausal abnormal bleeding 1991
- Preinvasive lesions of the endometrium 1991
- Effects of danazol, gonadotropin-releasing hormone agonist, and a combination of danazol and gonadotropin-releasing hormone agonist on experimental endometriosis 1990
Source provenance
- openalex
- last seen: 2026-05-11T05:56:47.744056+00:00
- pubmed
- last seen: 2026-10-08T21:26:25.435920+00:00
License: CC0
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