William D. Schlaff

Bone mineral density (BMD) changes during the life span, increasing rapidly during adolescence, plateauing in the third decade of life, and subsequently entering a phase of age-related decline. In women, menopause leads to accelerated bone …

OBJECTIVE: To review the available clinical evidence on the use of combined hormonal contraceptive (CHC) agents (estrogen [E]-progestin combinations) for the treatment of endometriosis-related pain. DESIGN: A systematic review of the MEDLIN…

Pain is among the foremost complaints of women seeking gynecological consultation, yet the diagnosis is often limited to endometriosis. Chronic Pelvic Pain discusses how to diagnose a broad scope of underlying conditions presenting in relat…

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Objectives: To determine if low-dose estrogen replacement can be added to GnRH agonist therapy after three months to reduce hypoestrogenic symptoms while allowing continued relief of pain in patients with endometriosis. Materials and Method…

Dr. Worly is Assistant Professor, and Dr. Schlaff is Professor and Chair, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut St, Ste 400, Philadelphia, PA 19107; E-mail: [email prot…

Dr. Worly is Assistant Professor, and Dr. Schlaff is Professor and Chair, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut St, Ste 400, Philadelphia, PA 19107; E-mail: [email prot…

Part I Reproductive Endocrinology and the Regulation of Menses Steroids and prostaglandins in reproductive medicine The normal Menstrual cycle Normal and abnormal pubertal development Primary amenorrhea Hyperandrogenic disorders and PCOS Se…

ObjectiveTo compare the efficacy and safety of SC depot medroxyprogesterone acetate (DMPA-SC 104) with that of leuprolide acetate in treatment of endometriosis.DesignPhase 3, multicenter, randomized, evaluator-blinded, comparator-controlled…

We investigated the prevalence of abnormal screening results (questionnaire and testing for other causes of oligo-ovulation, male or tubal factor infertility) in a group of 1,313 oligo-ovulatory women (included and excluded subjects) whose …

Amenorrhea is a common symptom that generally presents to the gynecologist for evaluation and therapy during adolescence. Its presence, in combination with an anomaly of the vagina and a pelvic mass, suggests many possible etiologies whose …

ObjectiveTo determine if extended treatment with doxycycline before and after an in vitro fertilization (IVF) procedure can minimize the detrimental effect of a hydrosalpinx.DesignRetrospective analysis.SettingUniversity IVF program.Patient…

The treatment of women with endometriosis can be a challenge. Therapeutic strategies must be tailored to the individual symptoms, age, and desire for fertility. Medical therapy continues to be based on endocrine treatment, such as oral cont…

PurposeOur purpose was to determine the effect of Synthetic Serum Substitute (SSS) versus serum supplementation on fertilization rates and subsequent development of embryos from patients undergoing IVF.ProcedureExperiment I compared the eff…

Patients undergoing human menopausal gonadotropin (hMG) superovulation were reviewed retrospectively to determine whether fecundity was greater for intrauterine insemination (IUI) than timed intercourse. Forty patients with unexplained infe…

The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of …

Between 1977-1989, 29 women with symptomatic endometriosis were treated with megestrol acetate by the Johns Hopkins Division of Reproductive Endocrinology. All had previously received one or more alternative medical treatments for endometri…

Ali et al reported last year (J Nucl Med 28(4): 628–629) no correlation between bone loss in leuprolide or danazol therapy, conflicting previous reports showing a correlation. We report the preliminary results on 6 patients ages 31–46 studi…