Superovulation with or without intrauterine insemination for the treatment of infertility.

Bradley S. Hurst, Hurst BS, B S Hurst, Tjaden BL, B L Tjaden, Bruce L. Tjaden, Abigail K. Kimball, A Kimball, Kimball A, William D. Schlaff, Schlaff WD, W D Schlaff, M D Damewood, Damewood MD, Marian D. Damewood, Rock JA, J A Rock, John A. Rock
The Journal of reproductive medicine · 1992 · vol. 37(3) , pp. 237–41 · PMID:1564710 · W2462279323
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Human menopausal gonadotropin with intrauterine insemination significantly increased pregnancy rates compared to human menopausal gonadotropin alone for infertile patients with a good prognosis.

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Abstract

Patients undergoing human menopausal gonadotropin (hMG) superovulation were reviewed retrospectively to determine whether fecundity was greater for intrauterine insemination (IUI) than timed intercourse. Forty patients with unexplained infertility, American Fertility Society I or II endometriosis, luteal phase defect and/or cervical factor were treated with hMG alone or hMG plus IUI. Twenty-eight underwent 52 cycles of hMG/IUI, and 19 underwent 31 cycles of hMG. The probability of pregnancy after four cycles was significantly better in the hMG/IUI group (.90) than the hMG group (.37, P = .049). There was a 54.5% multiple pregnancy rate, and one patient was admitted to the hospital for hyperstimulation. When traditional therapy fails, hMG/IUI significantly increases the pregnancy rates as compared to hMG with timed intercourse in a "good prognosis" group of patients.

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Condition tags

endometriosisinfertility

MeSH descriptors

Coitus Infertility, Female Insemination, Artificial, Homologous Pregnancy Outcome Superovulation Baltimore Baltimore Female Hospitals, University Humans Infertility, Female Infertility, Female Infertility, Female Insemination, Artificial, Homologous Life Tables Menotropins Menotropins Menotropins Pregnancy Prognosis

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