Yasushi Hirota
No ORCID on file
· 138 papers in corpus
· active 2002-2026
Study types
- article 107
- other 15
- preprint 5
- book-chapter 4
- review 4
Condition tags
- endometriosis 101
- adenomyosis 36
- endometrioma 27
- infertility 12
- dysmenorrhea 8
- mesh:D004716 2
- thoracic_endometriosis 1
- die_deep_infiltrating 1
- disambig:endometritis 1
- chronic_pelvic_pain 1
Top journals
Frequent coauthors
- Yutaka Osuga 133
- Kaori Koga 102
- Miyuki Harada 92
- Tomoyuki Hirata 92
- Osamu Yoshino 48
- Tomoyuki Fujii 46
- Yojiro Taketani 45
- Osamu Wada-Hiraike 44
- Gentaro Izumi 42
- Masashi Takamura 39
review
2010
Endometriosis is a disease characterized by the presence of endometriotic tissue outside the uterine cavity. Although its pathogenesis remains to be elucidated, immune status is suggested to play an important role in the initiation and the …
article
2010
Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…
article
2010
BACKGROUND: Regulation of decidualization is decisive for proper implantation and the establishment of pregnancy. Recent studies have suggested that several bone morphogenetic proteins (BMPs) play physiological roles in reproduction. In the…
article
2010
In a novel paradigm of T cell differentiation, type 17 T helper (Th17) cells may play a significant role in endometriosis, a chronic inflammatory disease. However, the mechanism regulating the accumulation of Th17 cells in endometriotic tis…
other
2009
OBJECTIVE: To determine possible involvement of splice variant 1 (SV1), a variant of the pituitary growth hormone-releasing hormone (GHRH) receptor, in the development of endometriosis. DESIGN: Comparative and laboratory study. SETTING: U…
article
2009
article
2009
BACKGROUND: The aim of this study was to evaluate the impact of post-operative oral contraceptives (OCs) use on the rate of recurrence after laparoscopic excision of ovarian endometrioma. METHODS: In May 2005, we introduced a 'post-operativ…
article
2009
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases such as trypsin, tryptase, and coagulation factors VIIa and Xa. A large body of evidence has shown that PAR2 plays an important rol…
article
2008
During the menstrual cycle, dynamic morphological changes are observed in the ovarian follicle and the endometrium. These changes are associated with the onset of the inflammatory response in which many proteinases play various roles. Throm…
article
2008
article
2008
article
2008
BACKGROUND: The increase in concentration of osteoprotegerin, an antagonist of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the peritoneal fluid of women with endometriosis may interfere with TRAIL-induced apoptosis i…
article
2007
article
2007
IL-17A is secreted from Th17 cells, a discovery leading to revision of the mechanism underlying the role of Th1/Th2 in the immune response. Strong evidence suggests that immune responses associated with inflammation are involved in the path…
article
2007
CONTEXT: Metformin, a widely used treatment for diabetes that improves insulin sensitivity, also has both antiinflammatory properties and a modulatory effect on ovarian steroid production, two actions that have been suggested to be efficaci…
article
2006
Adiponectin, a pleiotropic cytokine, exerts its effects via the specific receptors AdipoR1 and AdipoR2. Whereas circulating adiponectin concentrations decrease in women with endometriosis and endometrial cancer, possible effects of adiponec…
article
2006
article
2006
Both the classic form of the gonadotropin-releasing hormone receptor, GnRH I, and GnRH agonists reportedly have antiproliferative and apoptotic (programmed cell death) effects on cultured endometriotic cells as well as on some cancer cells …
article
2006
article
2006
BACKGROUND: To analyse risk factors that influence the recurrence of endometrioma after laparoscopic excision. METHODS: A total of 224 patients who had a minimum of 2 years of post-operative follow-up after laparoscopic ovarian endometrioma…
article
2005
BACKGROUND: Inflammation has been proposed to play essential roles in the pathophysiology of endometriosis, in which neutrophils and mast cells have been suggested to be involved. We studied whether the protease-activated receptor 2 (PAR2),…
article
2005
PROBLEM: Adiponectin is a novel adipocytokine of extreme importance for the metabolism. Recent studies have indicated that adiponectin suppresses inflammation, angiogenesis, and fibrosis, which are central pathogenic factors for endometrios…
article
2005
BACKGROUND: Aiming at improving an animal model of endometriosis, we developed a homologous mouse model using 'green mice' that ubiquitously express green fluorescent protein. METHODS: Endometrial fragment obtained from estradiol (E2)-suppl…
other
2005
OBJECTIVE: To investigate the role of interleukin (IL)-16 in peritoneal fluid in the pathogenesis of endometriosis. DESIGN: Comparative and laboratory study. SETTING: University of Tokyo Hospital. PATIENT(S): Peritoneal fluids (PFs) were…
article
2005
BACKGROUND: GnRH II is the second form of GnRH and is widely distributed in peripheral tissues of the female reproductive tract as well as in the central nervous system. In the present study, we studied the possible implication of GnRH II i…