Hiroji Okada

No ORCID on file · 15 papers in corpus · active 1983-2010

Study types

  • article 13
  • book-chapter 2

Condition tags

  • endometriosis 7
  • dysmenorrhea 1
  • infertility 1
  • adenomyosis 1
article 2010
·doi:10.1159/000292490

To examine antiestrogenic effects of danazol through the receptor system and to clarify its direct effects on the endometrium in vivo, we applied danazol jelly directly into the rabbit uterine cavity and measured uterine estrogen, progester…

article 1994
article 1993
American Journal of Obstetrics and Gynecology ·doi:10.1016/0002-9378(93)90654-2

ObjectiveTo investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis.Study designAromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatograph…

article 1993
·doi:10.1507/endocrine1927.69.10_1044

Danazol, an isoxazol derivative of 17 α-ethinyl-testosterone, has various effects on the female reproductive system. To examine its anti-estrogenic effects through the receptor system and clarify its direct effect on the endometrium in vivo…

article 1990
Journal of steroid biochemistry ·doi:10.1016/0022-4731(90)90167-q

The development of human uterine estrogen-dependent tumors is considered to be closely related to estrogen biosynthesis. This study examined whether or not 14 alpha-hydroxy-4-androstene-3,6,17-trione (14 alpha-OHAT), a new 4-androstene-3, 1…

article 1989
Acta endocrinologica ·doi:10.1530/acta.0.1210259

Estrogen biosynthesis (aromatase activity) was investigated in human adenomyosis tissue and compared with that of the normal myometrium, endometrium, and endometrial cancer tissues. Homogenates were incubated with [1,2,6,7-3H]androstenedion…

article 1989
·doi:10.1007/bf03349962

Aromatase activity for androstenedione was measured in stromal cells of human uterine endometrium throughout the menstrual cycle. The effect of progestogen on aromatase activity was also examined in the endometrial stromal cells. Aromatase …

article 1986
Acta obstetricia et gynecologica Scandinavica ·doi:10.3109/00016348609157380

To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human u…

article 1985
·doi:10.3109/00016348509155136

Abstract. To support the estrogen hypothesis in the patho‐genesis of leiomyoma, total cellular estrogen receptor (ER) levels (the sum of levels in cytosol and nuclear KCl‐extract‐able and nuclear non‐KCl‐extractable fractions) were assayed …

article 1985
Asia-Oceania journal of obstetrics and gynaecology ·doi:10.1111/j.1447-0756.1985.tb00760.x

Abstract The serum prolactin (PRL) levels of 34 cases of endometriosis, 26 cases of adeno‐m‐osis, 30 cases of functional d‐smenorrhea, and 9 patients with m‐oma uteri were measured b‐ radioimmunoassa‐. The incidence of h‐perprolactinemia (>…

article 1985
Asia-Oceania journal of obstetrics and gynaecology ·doi:10.1111/j.1447-0756.1985.tb00762.x

Abstract Nine patients with pelvic endometriosis were treated with gestrinone in a dose of 2.5 mg twice weekl‐ for 6 to 7 months. All patients became anovulator‐ with sporadic episodes of painless uterine bleeding lasting various periods of…

article 1984
Fertility and Sterility ·doi:10.1016/s0015-0282(16)47840-4

To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, proges…

book-chapter 1984
·doi:10.1007/978-94-009-5602-5_19
book-chapter 1984
·doi:10.1007/978-94-011-7621-7_24
article 1983
·doi:10.1111/j.1447-0756.1983.tb00621.x

Abstract The relation between serum hormone levels, endometrial cellular steroid receptor levels and endometrial dating was evaluated in the mid‐luteal phase of normoprolactinemic and hyperprolactinemic women for a better understanding of l…