Gestrinone (R2323) Binding to Steroid Receptors in Human Uterine Endometrial Cytosol
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Abstract
To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Gestrinone bound to endometrial receptors for estrogen, progesterone and androgen, but seemed not to bind to endometrial intracellular corticosteroid-binding globulin and sex hormone-binding globulin. Gestrinone occupies all specific binding sites of steroids in the steroid target cells despite the presence of endogenous steroids. It is speculated that the binding behavior of gestrinone may be related to its therapeutic effect on endometriosis. Gestrinone's more avid affinity for estrogen receptor may be the reason for the ability to use a lower clinical dose of gestrinone.
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References (12)
- Danazol Binding to Rat Androgen, Glucocorticoid, Progesterone, and Estrogen Receptors: Correlation With Biologic Activity via openalex
- Treatment of endometriosis with gestrinone (R-2323), a synthetic antiestrogen, antiprogesterone via openalex
- W1999848171 via openalex
- W2021892056 via openalex
- W2034976007 via openalex
- W2077460452 via openalex
- W2077893231 via openalex
- W2192305762 via openalex
- W2294353332 via openalex
- W1529950036 via openalex
- W6659055160 via openalex
- W1978600980 via openalex
Cited by (7)
- Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer 2022
- Effectiveness of treatment for infertility using clinical investigation of laparoscopy cytoreductive surgery combined with gestrinone in adenomyosis 2016
- Medical Treatments for Endometriosis-Associated Pelvic Pain 2014
- History of Endometriosis: A 20th‐Century Disease 2011
- Multicentre study of gestrinone in cyclical breast pain FRIEDOLF PETERS 1992
- Rationale for frequency and dose of administration in gestrinone therapy for pelvic endometriosis in the experimental model of rabbit uterus 1991
- Treatment of Pelvic Endometriosis with Gestrinone ‐Report on 9 Cases ‐ 1985
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- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:09:40.384591+00:00
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