Hiroji Okada

To examine antiestrogenic effects of danazol through the receptor system and to clarify its direct effects on the endometrium in vivo, we applied danazol jelly directly into the rabbit uterine cavity and measured uterine estrogen, progester…

Danazol, an isoxazol derivative of 17 α-ethinyl-testosterone, has various effects on the female reproductive system. To examine its anti-estrogenic effects through the receptor system and clarify its direct effect on the endometrium in vivo…

Estrogen biosynthesis (aromatase activity) was investigated in human adenomyosis tissue and compared with that of the normal myometrium, endometrium, and endometrial cancer tissues. Homogenates were incubated with [1,2,6,7-3H]androstenedion…

To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human u…

Abstract. To support the estrogen hypothesis in the patho‐genesis of leiomyoma, total cellular estrogen receptor (ER) levels (the sum of levels in cytosol and nuclear KCl‐extract‐able and nuclear non‐KCl‐extractable fractions) were assayed …

Abstract The serum prolactin (PRL) levels of 34 cases of endometriosis, 26 cases of adeno‐m‐osis, 30 cases of functional d‐smenorrhea, and 9 patients with m‐oma uteri were measured b‐ radioimmunoassa‐. The incidence of h‐perprolactinemia (>…

Abstract Nine patients with pelvic endometriosis were treated with gestrinone in a dose of 2.5 mg twice weekl‐ for 6 to 7 months. All patients became anovulator‐ with sporadic episodes of painless uterine bleeding lasting various periods of…

Abstract The relation between serum hormone levels, endometrial cellular steroid receptor levels and endometrial dating was evaluated in the mid‐luteal phase of normoprolactinemic and hyperprolactinemic women for a better understanding of l…