M. Kaufmann

Sphingolipids are important constituents of cell membranes, which play key roles as regulatory molecules for various cellular functions. Sphingosine-1-phosphate produced by sphingosine kinase 1 (SPHK1) promotes cell proliferation, regulates…

Cytokeratins are a multigene family of polypeptides expressed in distinct combinations along the various routes of epithelial differentiation. In endometrial cancer and cervical intraepithelial neoplasia/cervical squamous cell carcinoma, th…

OBJECTIVE: Enlargement of the junctional zone (JZ) on T2-weighted resonance imaging of the uterus has recently been established as the major criterion for adenomyosis in patients with endometriosis. This study was conducted to analyse the e…

Einleitung: Gewebeproben von peritonealer Endometriose, Adenomyose und von basalem Endometrium zeigten die gleichen zyklischen immunhistochemischen Veränderungen bezüglich der Hormonrezeptoren sowie der P-450 Aromatase*. Da beschrieben wurd…

Fragestellung: In letzter Zeit mehren sich die Hinweise, dass eine Adenomyose mit einer Prävalenz von bis zu 85% bei Endometriose vorliegt. Der Ausprägungsgrad der Adenomyose ist von entscheidender Bedeutung für die Fertilität der Patientin…

Hintergrund: Die Erweiterung der Übergangszone ("junctional Zone", JZ) in der Magnetresonanztomographie (MRI) gilt als Hauptkriterium der Adenomyose1. Da die schwere Dysmenorrhoe das Leitsymptom der Endometriose darstellt, aber nie mit eine…

The significance of retrograde menstruation as a risk factor for endometriosis has been confirmed by numerous clinical observations. Integrins mediate both cell-cell and cell-matrix adhesion, and it is therefore suspected that integrins are…

Bleeding disorders are one of the most frequent gynecological problems. The causes of bleeding disorders, and their frequency in particular, vary depending on the age of the woman affected. In premenopause and perimenopause, the most freque…

Peritoneum und das innere Genitale der Frau stammen beide vom embryonalen Zölomepithel ab. Vor diesem Hintergrund ist eine Hypothese zur Entstehung der Endometriose, dass sich diese durch Metaplasie aus dem Peritoneum entwickelt. In der emb…

OBJECTIVE: Uterine hyperperistalsis and dysperistalsis are common phenomena in endometriosis and may be responsible for reduced fertility in cases of minimal or mild extent of disease. Since a high prevalence of adenomyosis uteri has been w…

OBJECTIVE: To investigate uterotubal transport by means of hysterosalpingoscintigraphy (HSSG) in women with and without endometriosis. DESIGN: A prospective observational study. SETTING: University Hospital, Department of Obstetrics and G…

endometriums with endometriosis, which were labeled with Cy5-dUTP. Fluorescent labeled probes were hybridized on a microarray of 4800 human genes. Results: We could detect many genes expressed differently in eutopic endometrium with or with…

Hintergrund: Gewebe von Endometriose-und Adenomyoseherden imitieren die zyklischen Veränderungen der Hormonrezeptoren des basalen Endometriums. Da der Nachweis erbracht wurde, dass bei Patientinnen mit Endometriose eine höhere Prävalenz an …

Endometriosis and adenomyosis show a high prevalence and can be regarded as different symptoms of a unique disease - the dislocation of basal endometrium. Diagnostic methods for detecting adenomyosis are transvaginal sonography (TVS) or T-2…

PURPOSE: To evaluate the clinical value of magnetic resonance imaging (MRI) of the uterus and the pelvis in infertile female with symptomatic endometriosis for the assessment of uterine morphology and function. MATERIALS AND METHODS: Forty…

Fragestellung: Endometriose und Adenomyose sind als unterschiedliche Verlaufsformen einer gemeinsamen Grunderkrankung zu verstehen – einer Dislokation basalen Endometriums.

Fragestellung: Endometriose und Adenomyose sind als unterschiedliche Verlaufsformen einer gemeinsamen Grunderkrankung zu verstehen – einer Dislokation basalen Endometriums.

A 53-year-old women underwent D & C and diagnostic hysteroscopy for suspected endometrial hyperplasia, when the posterior uterine wall was perforated. An endometrial polyp prolapsed into the abdominal cavity after uterine rupture which was …

Zielsetzung: Endometriose und Adenomyose sind als unterschiedliche Verlaufsformen einer gemeinsamen Grunderkrankung zu verstehen – einer Dislokation basalen Endometriums. Ungeklärt ist die Frage, warum bei milder und moderater Endometriose …

OBJECTIVE: Ovarian cancer antigen CA 125 is used widely for diagnostic and therapeutic evaluation of ovarian cancer. Although the initial description of CA 125 was in 1981, its function is still unknown. In collagen gel system the invasiven…

A hysteroscopic endometrial ablation (HEA) under maximal anesthesiologic surveillance was performed on 34 high-risk patients (group I: chronic anticoagulant therapy n = 26; group II: endogenous coagulopathy n = 8) with therapy resistant men…

Hysteroscopic endometrial ablation under maximal anaesthesiological surveillance was performed in 34 high-risk patients to avoid hysterectomy. It was a collective of patients with heavy thrombo-embolic or thrombotic disease, either under pe…

An extraovarian peritoneal serous carcinoma is characterised macroscopically by ovaries without pathology, histologically, however, by a serous carcinomatous structure in the pelvis, in an advanced tumour stage of usually marked peritoneal …