Hysteroskopische Endometriumablation zur Vermeidung einer Hysterektomie bei “High-Risk”-Patientinnen

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Hysteroscopic endometrial ablation successfully treated 28 of 34 high-risk patients, avoiding hysterectomy in most by achieving amenorrhea or hypomenorrhea.

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This study evaluated hysteroscopic endometrial ablation as a surgical alternative to hysterectomy for 34 high-risk patients with severe thrombo-embolic disorders or coagulopathies that contraindicated major surgery. Under strict anesthetic monitoring, the procedure successfully induced amenorrhea or significant bleeding reduction in 28 of the 34 participants, thereby avoiding the life-threatening risks associated with hysterectomy in this specific population. However, two patients required subsequent hysterectomy due to extensive adenomyosis uteri interna, and two others died from unrelated cardiac or cerebrovascular events during follow-up periods ranging from one to five years. Relevance to endometriosis: The paper explicitly mentions adenomyosis as a condition requiring hysterectomy in two cases, positioning it within the context of abnormal uterine bleeding management rather than focusing on endometriosis itself.

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Abstract

Hysteroscopic endometrial ablation under maximal anaesthesiological surveillance was performed in 34 high-risk patients to avoid hysterectomy. It was a collective of patients with heavy thrombo-embolic or thrombotic disease, either under permanent anticoagulation due to residual disease or multiple endoprosthetic treatment, or with endogenous coagulopathy. In all these women, hysterectomy was either a relative or an absolute contraindication. In 22 patients, treatment resulted in complete amenorrhoea or at least hypomenorrhoea (without menometrorrhagia) respectively cyclic spotting. In 6 further patients, amenorrhoea was achieved after a repeat procedure. Endometrial ablation was thus successful in 28 of 34 cases. In these patients, hysterectomy with the risk of major or even lethal complications, could thus be avoided. Hysterectomy, however, had to be performed in 2 women with extensive adenomyosis uteri interna. Within two respectively three years after endometrial ablation, two other patients died from causes unrelated to the surgical intervention (cardiac infarction, cerebral haemorrhage). Follow-up ranged from 1 to 5 years. Hysteroscopic endometrial ablation proved an effective therapeutic option in this selected group of patients. Other indications require further study.
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Subscribe to RSS DOI: 10.1055/s-2007-1022325 © Georg Thieme Verlag Stuttgart · New York Hysteroskopische Endometriumablation zur Vermeidung einer Hysterektomie bei “High-Risk”-Patientinnen Hysteroscopic Endometrial Ablation to Avoid Hysterectomy in High-Risk PatientsPublication History Publication Date: 18 March 2008 (online) Zusammenfassung Zur Vermeidung einer Hysterektomie wurde bei 34 “High-Risk”-Patientinnen mit schweren thrombo-embolischen oder thrombotischen Erkrankungen, die aufgrund der Residualzustände bzw. aufgrund multipler endoprothetischer Versorgungen permanent antikoaguliert waren oder die schwere endogene Koagulopathien mit relativer oder absoluter Kontraindikation zur Hysterektomie aufwiesen, unter maximaler anästhesiologischer Überwachung eine hysteroskopische Endometriumablation durchgeführt. Bei 22 Patientinnen konnte eine komplette Amenorrhö oder zumindest eine nicht mehr in eine Menometrorrhagie mündende Hypomenorrhö bzw. lediglich ein zykluskorrespondierendes Spotting erzielt werden. Bei weiteren 6 Patientinnen resultierte nach Wiederholung des Eingriffs ebenfalls eine Amenorrhö. Somit war bei 28 von 34 Patientinnen eine erfolgreiche Therapie durchgeführt und eine Hysterektomie mit zu befürchtenden schwerwiegenden oder sogarfatalen Komplikationen vermieden worden. Bei 2 Patientinnen mußte eine Hysterektomie bei ausgeprägter Adenomyosis uteri interna durchgeführt werden, 2 Patientinnen verstarben 2 bzw. 3 Jahre nach der Endometriumablation an einem Herzinfarkt bzw. einem zerebralen Insult. Die Dokumentation stützt sich auf eine Nachbeobachtung von mindestens einem, längstens 5 Jahren. Somit konnte gezeigt werden, daß die hysteroskopische Endometriumablation als effektive therapeutische Alternative in einem zum jetzigen Zeitpunkt noch streng selektierten Indikationsbereich gelten kann. Abstract Hysteroscopic endometrial ablation under maximal anaesthesiological surveillance was performed in 34 high-risk patients to avoid hysterectomy. It was a collective of patients with heavy thrombo-embolic or thrombotic disease, either under permanent anticoagulation due to residual disease or multiple endoprosthetic treatment, or with endogenous coagulopathy. In all these women, hysterectomy was either a relative or an absolute contraindication. In 22 patients, treatment resulted in complete amenorrhoea or at least hypomenorrhoea (without menometrorrhagia) respectively cyclic spotting. In 6 further patients, amenorrhoea was achieved after a repeat procedure. Endometrial ablation was thus successful in 28 of 34 cases. In these patients, hysterectomy with the risk of major or even lethal complications, could thus be avoided. Hysterectomy, however, had to be performed in 2 women with extensive adenomyosis uteri interna. Within two respectively three years after endometrial ablation, two other patients died from causes unrelated to the surgical Intervention (cardiac infarction, cerebral haemorrhage). Follow-up ranged from 1 to 5 years. Hysteroscopic endometrial ablation proved an effective therapeutic option in this selected group of patients. Other indications require further study.

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Condition tags

adenomyosis

MeSH descriptors

Endometrium Hemorrhagic Disorders Hysterectomy Hysteroscopy Postoperative Complications Thromboembolism Uterine Hemorrhage Adult Electrocoagulation Endometrium Endometrium Female Follow-Up Studies Hemorrhagic Disorders Humans Leiomyoma Leiomyoma Middle Aged Postoperative Complications Risk Factors

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