[New aspects in diagnosis and therapy of endometriosis]

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This review discusses endometriosis and adenomyosis as a single disease, highlighting TVS and MRI for diagnosis, the impact on fertility, and hormonal suppression for fertility preservation.

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Abstract

Endometriosis and adenomyosis show a high prevalence and can be regarded as different symptoms of a unique disease - the dislocation of basal endometrium. Diagnostic methods for detecting adenomyosis are transvaginal sonography (TVS) or T-2-weighed magnetic resonance imaging (MRI). Patients with endometriosis show a significant impairment of utero-tubal sperm transport capacity, which is even increased the stronger the adenomyotic component of the disease is. Adenomyosis can be regarded as a cause for infertility especially in minor and mild forms of endometriosis and is therefore often followed by IVF/ICSI-treatment. Infertility patients with endometriosis should be counselled for intensive infertility treatment. Without a current wish for conception, fertility potential should be preserved by hormonal suppression of uterine peristalsis in order to avoid progression of the disease.
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Subscribe to RSS DOI: 10.1055/s-2004-820382 © Georg Thieme Verlag Stuttgart · New York Neues in Diagnostik und Therapie der Endometriose Kongress Gynäkologie u. Geburtshilfe, 13./14.2.2004, FrankfurtNew Aspects in Diagnosis and Therapy of EndometriosisPublication History Publication Date: 12 October 2004 (online) Zusammenfassung Endometriose und Adenomyose zeigen eine hohe Prävalenz und können als unterschiedliche klinische Erkrankungsbilder einer gemeinsamen Erkrankung gesehen werden - der Dislokation basalen Endometriums. Methoden der Diagnostik der Adenomyose sind die hochauflösende Transvaginalsonographie (TVS) so wie die T-2-gewichtete Magnetresonanztomographie (MRI). Patientinnen mit Endometriose zeigen in vivo eine Störung des Spermientransportes, die direkt von der adenomyotischen Komponente abhängt. Dies dient als Erklärung des Phänomens der weiblichen Infertilität auch bei minimalen bis milden Formen der Endometriose und zieht häufig die IVF/ICSI-Therapie nach sich. Patientinnen mit Kinderwunsch sollten deshalb rasch einem Kinderwunschzentrum zugeführt werden. Intrauterine Inseminationen sollten nur über einen begrenzten Zeitraum durchgeführt werden. Besteht kein akuter Kinderwunsch, so ist bei Patientinnen mit Endometriose eine hormonelle Suppression des Zyklus und damit der uterinen Peristaltik angezeigt, um ein Fortschreiten vor allem der adenomyotischen Komponente zu verhindern. Abstract Endometriosis and adenomyosis show a high prevalence and can be regarded as different symptoms of a unique disease - the dislocation of basal endometrium. Diagnostic methods for detecting adenomyosis are transvaginal sonography (TVS) or T-2-weighed magnetic resonance imaging (MRI). Patients with endometriosis show a significant impairment of utero-tubal sperm transport capacity, which is even increased the stronger the adenomyotic component of the disease is. Adenomyosis can be regarded as a cause for infertility especially in minor and mild forms of endometriosis and is therefore often followed by IVF/ICSI-treatment. Infertility patients with endometriosis should be counselled for intensive infertility treatment. Without a current wish for conception, fertility potential should be preserved by hormonal suppression of uterine peristalsis in order to avoid progression of the disease. Schlüsselwörter Endometriose - Adenomyose - MRI - Spermientransport Key words Endometriosis - adenomyosis - MRI - sperm transport Literatur - 1 Sampson J A. Peritoneal endometriosis due to the peritoneal dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynaecol. 1927; 14 422-429 - 2 Meyer R. Über den Stand der Adenomyositis und Adenome im Allgemeinen und insbesondere über Adenomypsitis seroepithelialis und Adenomyometritis sarcomatosa. Zbl Gynäkol. 1919; 43 745-750 - 3 Leyendecker G, Herbertz M, Kunz G, Mall G. Endometriosis results from the dislocation of basal endometrium. Hum Reprod. 2002; 17 2725-2736 - 4 Kunz G, Herbertz M, Noe M, Leyendecker G. Sonographic evidence of a direct impact of the ovarian dominant structure on uterine function during the menstrual cycle. Hum Reprod Update. 1998; 4 667-672 - 5 Wildt L, Kissler S, Licht P, Becker W. Transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography. Hum Reprod Update. 1998; 4 655-666 - 6 Leyendecker G, Kunz G, Noe M, Herbertz M, Beil D, Huppert P, Mall G. Die Archimetra als neues morphologisch-funktionelles Konzept des Uterus sowie als Ort der Primäerkrankung bei Endometriose. Reproduktionsmedizin. 1999; 15 356-371 - 7 Kissler S, Wildt L, Kaufmann M, Siebzehnrübl E. Gestörte uterine Transportfunktion in der Hysterosalpingoszintigraphie (HSSG) als prädiktiver Funktionstest für die Durchführung einer IVF-Therapie. Zbl Gynäkol. 2002; 124 1-5 - 8 Sammour A, Pirwany I, Usubutun A, Arseneau J, Tulandi T. Correlations between extent and spread of adenomyosis and clinical symptoms. Gynecol Obstet Invest 2002; 213-216 - 9 Fauconnier A, Chapron C, Dubuisson J B, Vieira M, Dousset B, Breart G. Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis. Fertil Steril. 2002; 78 719-726 - 10 Rickes D, Nickel I, Kropf S, Kleinstein J. Increased pregnancy rates after ultra-long postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis. Fertil Steril. 2002; 78 757-761 - 11 Vercellini P, Frontino G, De Giorgi O, Pietropaolo G, Pasin R, Crosignani P G. Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril. 2003; 80 560-563 - 12 Vercellini P, Fedele L, Pietropaolo G, Frontino G, Somogliana E, Crosignani P G. Progestogens for endometriosis: forward to the past. Hum Reprod Update. 2003; 9 387-396 - 13 Vercellini P, Aimi G, Panazza S, De Giorgi O, Pesole A, Crosignani P G. A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study. Fertil Steril. 1999; 72 505-508 Dr. med. S. Kissler Klinikum der Johann-Wolfgang-Goethe-Universität · Klinik für Gynäkologie und Geburtshilfe Theodor-Stern-Kai 7 60590 Frankfurt am Main Phone: 0 69/63 01-57 08 Fax: 0 69/63 01-41 20 Email: [email protected]

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Condition tags

mesh:D004715endometriosisadenomyosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Female Fertility Humans Infertility, Female Infertility, Female Magnetic Resonance Imaging Male

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