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BackgroundTo investigate the long-term systemic effects of tubal sterilisation using the silver clip technique, a commonly used yet understudied permanent contraceptive method, by evaluating its impact on inflammatory responses and coagulat…

Ovarian response to controlled ovarian stimulation (COS) is a core determinant of assisted reproductive technology (ART) success, with marked interindividual variability. Accurate and individualized prediction is essential to optimize treat…

OBJECTIVE: Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to explore the associ…

BackgroundVaricocoele is a common cause of male infertility, affecting spermatogenesis through increased testicular temperature, venous stasis, and oxidative stress. Microsurgical subinguinal varicocelectomy improves semen quality, whereas …

[This corrects the article DOI: 10.3389/fendo.2025.1735567.].

Primary dysmenorrhea is currently an unresolved public health problem worldwide, which suffers the patients comprehensive symptoms. Currently, more and more studies have been focusing on biomarker exploration for diagnosis and target therap…

Graphical abstractAbstractThe endometrium is the primary site of embryo implantation. Cellular senescence within the endometrium can be broadly categorised into normal cyclical senescence and pathological excessive senescence. Normal cyclic…

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is an endometriosis-associated ovarian cancer subtype. Somatic mutations in OCCC are reported in ARID1A, PIK3CA, and the TERT promoter (TERTp), as well as less commonly in KRAS and TP53 among …

Objectives: This research sought to examine the impact of gossypol on cervical cancer tumors that have been transplanted subcutaneously in nude mice, as well as the associated risk of liver damage and its underlying mechanisms. Methods: A s…

Background and objectiveIleal ureter replacement (IUR) is the definitive management approach for extensive ureteral strictures (UrSs). Patients with UrS exhibit poor health-related quality of life (HRQoL). We conducted a long-term, multi-in…

BackgroundThe ovary is a vital and dynamic reproductive organ. Ovarian tissue cryopreservation (OTC) plays a vital role in preserving female fertility. However, the cellular subtypes most susceptible to cryoinjury and the molecular mechanis…

BackgroundChronic endometritis (CE), characterized by CD138+ plasma cell infiltration, has been proposed to impair reproductive outcomes in assisted reproductive technology (ART). However, current evidence remains inconsistent, and diagnost…

Blood-based liquid biopsies hold transformative potential for non-invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating…

Abstract Background Progressive fibrosis of ectopic lesions is a major pathological feature of endometriosis, contributing to treatment resistance and disease recurrence. However, the mechanisms driving this fibrotic process remain incomp…

This retrospective study investigated risk factors and clinical outcomes of placenta accreta in pregnancies complicated by pernicious placenta previa (PPP). A total of 177 women diagnosed with PPP and treated at our institution between July…

Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report that transcript…

BackgroundImplantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful implant…

BACKGROUND: Endometriosis, a common chronic gynecological disorder, involves cellular autophagy and inflammatory processes in its pathogenesis. However, the specific regulatory mechanisms of autophagy and inflammation in endometriosis remai…

BACKGROUND: This study investigates whether the timing of first sexual intercourse is associated with the risk of developing endometriosis and adenomyosis, aiming to shed light on early-life reproductive factors that may influence women's l…

ObjectiveTo evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation.DesignMulticentre, double blind, placebo controlled, randomised clinical trial.Settin…

ObjectivesAcute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis are recognized as a continuum of pancreatic diseases. Recurrence increases the risk of progression to chronic pancreatitis. The aim of this study was to se…

The aim of this study is to investigate the mechanism of action and correlation between transforming growth factor beta 1 (TGF-β1) and β-catenin in pelvic organ prolapse (POP). The study compared vaginal wall tissues from two groups: 20 pat…

Air pollution has reproductive toxicity, while green space could lessen such harmful consequences. However, the current research on the link between air pollution/green space, and endometriosis remains scarce. Therefore, we investigated the…

Endometriosis is a complex, chronic inflammatory gynecological disorder with estrogen‑dependent characteristics that severely impairs the quality of life of women and potentially leads to infertility. However, its pathogenesis remains poorl…

BACKGROUND: Fibrogenesis is a common pathological feature of endometriotic lesions and contributes to the development of endometriosis-associated chronic pelvic pain and infertility. TGF-β is a critical factor in the induction of fibrogenes…