Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Print ISSN: 1107-3756 Online ISSN: 1791-244X International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Review - Authors: - Article Number: 32|Published online on: December 1, 2025https://doi.org/10.3892/ijmm.2025.5703 - Expand metrics + Endometriosis is a complex, chronic inflammatory gynecological disorder with estrogen‑dependent characteristics that severely impairs the quality of life of women and potentially leads to infertility. However, its pathogenesis remains poorly understood. Exosomes, small, discoid vesicles released by nearly all cell types, serve essential functions in multiple biological processes, including immune evasion, cellular migration, and differentiation. These vesicles can transport a broad repertoire of bioactive molecules, cross cell membranes readily, and remain stable within cells and body fluids. The present review summarizes global research from the last two decades on the mechanistic associations between exosomes and endometriosis, emphasizing their potential as vehicles for therapeutic delivery. Notably, the biological hallmarks of endometriosis such as fibrosis, immune dysregulation, angiogenesis, and aberrant cellular proliferation and migration, align with exosomal functions, suggesting that exosomes may contribute to disease progression. Furthermore, the use of exosomes as natural carriers for endometriosis treatment has been proposed, suggesting novel therapeutic avenues. Copy and paste a formatted citation Spandidos Publications style Chen W, Ma Y, Zhang X, Zhang S, Wu S, Lu Y and Tan J: Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review). Int J Mol Med 57: 32, 2026. APA Chen, W., Ma, Y., Zhang, X., Zhang, S., Wu, S., Lu, Y., & Tan, J. (2026). Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review). International Journal of Molecular Medicine, 57, 32. https://doi.org/10.3892/ijmm.2025.5703 MLA Chen, W., Ma, Y., Zhang, X., Zhang, S., Wu, S., Lu, Y., Tan, J."Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)". International Journal of Molecular Medicine 57.2 (2026): 32. Chicago Chen, W., Ma, Y., Zhang, X., Zhang, S., Wu, S., Lu, Y., Tan, J."Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)". International Journal of Molecular Medicine 57, no. 2 (2026): 32. https://doi.org/10.3892/ijmm.2025.5703