Increased incidence and recurrence of recent corpus luteum without ovulation stigma (luteinized unruptured follicle syndrome?) in baboons with endometriosis

T M D'Hooghe, Thomas D’Hooghe, D'Hooghe TM, Bambra CS, Charanjit S. Bambra, C S Bambra, Raeymaekers BM, B M Raeymaekers, Barbara M. Raeymaekers, Koninckx PR, Philippe R. Koninckx, P R Koninckx
Journal of the Society for Gynecologic Investigation · 1996 · vol. 3(3) , pp. 140–144 · doi:10.1177/107155769600300307 · PMID:8796822 · W2038938650
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This study found an increased incidence and recurrence of luteinized unruptured follicles in baboons with endometriosis, potentially indicating a link to luteinized unruptured follicle syndrome.

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Abstract

OBJECTIVE: To test the hypothesis that a recent corpus luteum (CL) without fresh ovulation stigma (OS) can be found with a higher incidence and recurrence in baboons with endometriosis and is associated with a reduced egg recovery rate after uterine flush. METHODS: One hundred thirty-eight laparoscopies were performed in the early luteal phase of 52 cycles in 32 female baboons with a normal pelvis (controls) and of 86 cycles in 21 animals with endometriosis. The incidence and recurrence of a recent CL without OS was studied during each laparoscopy and during the first three laparoscopies in 15 baboons (five controls, ten with endometriosis), respectively. The association between the presence of a recent CL without OS and the egg recovery rate was evaluated during 65 cycles in 21 baboons after uterine flush. RESULTS: When all 138 laparoscopies were analyzed, the incidence of a recent CL without OS was higher (P < .03) in animals with stage II-IV endometriosis (35%) than in those with stage I disease (19%) or controls (11%). Both the incidence (seven of ten) and recurrence (three of ten) of a recent CL without OS were higher in baboons with endometriosis than in controls (zero of five, P < .02) when studied during the first three laparoscopies. Laparoscopies in primates having a recent CL without OS were associated with a lower egg recovery rate (13%) than in animals with recent CL and OS (54%, P = .005). CONCLUSION: A recent CL without OS was associated with a reduced egg recovery rate and could be found with a higher incidence and recurrence in baboons with endometriosis than in controls, suggesting that luteinized unruptured follicle syndrome exists and could contribute to endometriosis-associated subfertility.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Primate Diseases Primate Diseases Animals Animals Corpus Luteum Corpus Luteum Endometriosis Endometriosis Endometriosis Endometriosis Female Female Incidence Incidence Laparoscopy Laparoscopy Laparoscopy Ovarian Diseases

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References (27)

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