Association rate between deep peritoneal endometriosis and other forms of the disease: pathogenetic implications

Edgardo Somigliana, Mirco Infantino, Infantino M, Massimo Candiani, Michele Vignali, Annalisa Chiodini, Chiodini A, Busacca M, Mauro Busacca, Vignali M, Mario Vignali
Human Reproduction · 2003 · vol. 19(1) , pp. 168–171 · doi:10.1093/humrep/deg513 · PMID:14688177 · W2135653031
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This study found high rates of co-occurrence between deep peritoneal endometriosis and superficial implants, endometriomas, and adhesions, suggesting a common pathogenetic mechanism rather than distinct disease entities.

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Abstract

BACKGROUND: It has been suggested recently that deep endometriosis and the other forms of the disease do not share a common pathogenetic mechanism. In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated. METHODS: Clinical and surgical records of all women who were referred to the Department of Obstetrics and Gynecology, Clinica 'L.Mangiagalli' between January 1995 and June 2002 and who were diagnosed with deep peritoneal pelvic endometriosis at the time of surgery were retrieved. The concomitant presence of superficial endometriotic implants, endometriomas and pelvic adhesions was evaluated. A binomial probability distribution model was used to calculate the 95% confidence interval (95% CI) of the association rates. RESULTS: Ninety-three women with deep peritoneal endometriosis were identified. The presence of superficial endometriotic implants, endometriomas and pelvic adhesions was documented in 61.3% (95% CI 51.4-71.2%), 50.5% (95% CI 40.3-60.7%) and 74.2% (95% CI 65.3-83.1%) of patients with deep endometriotic nodules, respectively. Overall, deep peritoneal endometriosis was the only form of the disease in only 6.5% (95% CI 2.8-12.3%) of cases. No relevant differences regarding these associations were observed according to the location and the size of the deep endometriotic nodules. CONCLUSIONS: Results from this study do not support the hypothesis that deep endometriosis should be considered as a distinct entity of the disease.

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Condition tags

endometriosis

MeSH descriptors

Adnexal Diseases Endometriosis Endometriosis Peritoneal Diseases Peritoneal Diseases Tissue Adhesions Adnexal Diseases Adnexal Diseases Adnexal Diseases Adult Adult Confidence Intervals Confidence Intervals Cysts Cysts Cysts Cysts Endometriosis Endometriosis Female

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