Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study
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This study examined deep infiltrating endometriosis (DIE) lesion distribution in 304 patients with ovarian endometrioma (OEM), finding unilateral OEM associated with more numerous DIE lesions, particularly in the intestine and vagina.
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This observational clinical study used retrospective data from 304 women (June 2008–June 2016) who underwent laparoscopic surgery with complete removal of endometriosis by one surgeon, including histologically confirmed ovarian endometrioma (OEM) associated with deep infiltrating endometriosis (DIE). The authors mapped DIE lesion distribution across recorded anatomical sites and compared lesion number and locations by OEM laterality (unilateral vs bilateral) and, within unilateral OEM, by side and size (≤50 vs >50 mm), with limitations including its single-center retrospective design and lesion counts restricted to sites documented during surgery. DIE lesions involved 30 anatomical sites and were multifocal, with unilateral OEM associated with a higher mean number of DIE lesions than bilateral OEM (2.76±1.52 vs 2.33±1.34). Unilateral OEM also showed higher infiltration rates of the intestine and vagina, while lesion number was not significantly correlated with OEM location or size. This paper is centrally about endometriosis — it characterizes lesion distribution of deep infiltrating endometriosis in relation to ovarian endometrioma, directly addressing endometriosis patterns alongside ovarian disease extent.
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Abstract
Abstract Purpose: To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM). Methods:The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Clinical data were recorded for each patient from medical, operative and pathological reports. Patients were then divided into two groups according to unilateral or bilateral OEM. Patients with unilateral OEM were subsequently divided into two subgroups according to OEM location (left- or right-hand side) and the diameter of the OEM (≤50 and >50 mm). The distribution characteristics of DIE lesions were then compared between the groups. Results:DIE lesions were widely distributed, 30 anatomical sites were involved. Patients with associated unilateral OEM (n=184 patients) had a significantly increased number of DIE lesions when compared with patients with bilateral OEM (n=120 patients; 2.76±1.52 vs. 2.33±1.34; P=0.006). Compared with bilateral OEM with DIE, there was a higher rate of intestinal (39.1% vs. 18.3%; P<0.01) and vaginal (17.4% vs. 6.7%; P<0.01) infiltration by DIE lesions in unilateral OEM with DIE. The mean number of DIE lesions was not significantly correlated with the location or size of the OEM (2.83±1.56 vs. 2.74±1.53; P=0.678; and 2.65±1.42 vs. 2.80±1.43; P=0.518, respectively). There was no significant difference between the groups with OEM ≤50 mm and >50 mm. Conclusion:Lesion distribution characteristics in women diagnosed with histologically proven OEM associated with DIE were frequently multifocal and severe.
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Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study Hungling Kwok, Hongye Jiang, Tian Li, Huan Yang, Hui Fei, Li Cheng, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.19864/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 20 May, 2020 Read the published version in BMC Women's Health → Version 1 posted 19 You are reading this older preprint version Read the latest preprint version → Show more versions Abstract Purpose: To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM). Methods:The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Clinical data were recorded for each patient from medical, operative and pathological reports. Patients were then divided into two groups according to unilateral or bilateral OEM. Patients with unilateral OEM were subsequently divided into two subgroups according to OEM location (left- or right-hand side) and the diameter of the OEM (≤50 and >50 mm). The distribution characteristics of DIE lesions were then compared between the groups. Results:DIE lesions were widely distributed, 30 anatomical sites were involved. Patients with associated unilateral OEM (n=184 patients) had a significantly increased number of DIE lesions when compared with patients with bilateral OEM (n=120 patients; 2.76±1.52 vs. 2.33±1.34; P=0.006). Compared with bilateral OEM with DIE, there was a higher rate of intestinal (39.1% vs. 18.3%; P<0.01) and vaginal (17.4% vs. 6.7%; P<0.01) infiltration by DIE lesions in unilateral OEM with DIE. The mean number of DIE lesions was not significantly correlated with the location or size of the OEM (2.83±1.56 vs. 2.74±1.53; P=0.678; and 2.65±1.42 vs. 2.80±1.43; P=0.518, respectively). There was no significant difference between the groups with OEM ≤50 mm and >50 mm. Conclusion:Lesion distribution characteristics in women diagnosed with histologically proven OEM associated with DIE were frequently multifocal and severe. Obstetrics & Gynecology ovarian endometrioma deep infiltrating endometriosis lesion distribution characteristics Full Text Tables Table I Preoperative characteristics of the study population . Patients’ characteristics (N= 304 ) Values a Age(years) 34.2 ± 5.8 (range17-49) Parity Para ≥1 158(52.0 % ) Nulliparous 146(48.0 % ) Infertility 78(25.7 % ) P revious surgery for OEM 88(28.9 % ) Presenting symptoms b No symptoms 32(10.5 % ) Dysmenorrhea 272(89.5 % ) D yspareunia 39(12.8 % ) Chronic pelvic pain 17(5.6 % ) Anus bulge 73(24.0 % ) Difficulty in defecation 13(4.3 % ) Diarrhea 6(2.0 % ) Defecation pain 11(3.6 % ) Hematochezia 8(2.6 % ) Urinary frequency and urgency 9(3.0 % ) Haematuria 2(0.7 % ) H ydronephrosis 26(8.6 % ) Endometrioma laterality Left 98(32.2 % ) Right 86(28.3 % ) Bilateral 120(39.5 % ) Endometrioma size (mm) 55.9 ± 23.9 (range10-150) Number of DIE lesions 2.60 ± 1.5 (range1-9) OEM, ovarian endometrioma; DIE, deep infiltrating endometriosis. a Values are shown as mean ± standard deviation or N(%). b Different symptoms can be associated in the same patient. Table II The prevalence of a natomical distribution of DIE lesions. (n=304 patients) Main lesion a Number of patients(%) b Uterosacral ligament 245(80.6) Left 57 Right 53 Bilateral 135 Rectum 93(30.6) Ureter 47(15.5) Left 22 Right 18 Bilateral 7 Vaginal 40(13.2) Posterior fornix 33(10.9) Fallopian tube 29(9.54) Left 12 Right 4 Bilateral 13 Vaginal rectum 21(6.91) Rectovaginal pouch 9(2.96) Bladder 4(1.32) DIE, deep infiltrating endometriosis. a According to the location of the lesion recorded during the operation. b Number of patients whose lesions histologically proven deep infiltrating endometriosis. Table III Characteristics of deeply infiltrating endometriosis lesion distribution associated ovarian endometrioma. Variables Comparison P -value OR 95% CI OEM laterality a Unilateral n=184 (%) Bilateral n=120 (%) Number of DIE lesions 2.76 ± 1.52 2.33 ± 1.34 0.006 * Uterosacral ligament 151(82.1) 94(78.3) 0.421 1.266 0.712-2.249 Intestine 72(39.1) 21(17.5) 0.000 * 3.031 1.738-5.286 Vagina 32(17.4) 8(6.70) 0.007 * 2.947 1.308-6.641 Posterior fornix 23(12.5) 10(8.3) 0.100 1.571 0.720-3.431 Ureter 29(15.8) 18(15.0) 0.858 1.060 0.560-2.009 Fallopian tube 19(10.3) 10(8.3) 0.563 1.267 0.568-2.827 Rectovaginal pouch 16(8.7) 14(11.7) 0.396 0.767 0.359-1.637 Side of OEM a Left side n= 98(%) Right side n= 86 (%) Number of DIE lesions 2.83±1.56 2.74±1.53 0.678 Uterosacral ligament 81(82.7) 70(81.4) 0.824 1.089 0.512-2.315 Intestine 40(40.8) 32(37.2) 0.617 1.164 0.642-2.109 Vagina 18(18.4) 15(17.4) 0.870 1.065 0.500-2.268 Posterior fornix 15(15.3) 8(9.3) 0.219 1.762 0.078-4.386 Ureter 16(16.3) 13(15.1) 0.822 1.096 0.494-2.431 Fallopian tube 8(8.2) 11(12.8) 0.303 0.606 0.232-1.584 Rectovaginal pouch 9(9.2) 7(8.1) 0.802 1.141 0.406-3.207 Unilateral OEM size a ≤ 50mm n=112 (%) >50mm n=72 (%) Number of DIE lesions 2.77 ± 1.4 2.82 ± 1.4 0.960 Uterosacral ligament 87(77.7) 64(88.9) 0.053 0.435 0.184-1.027 Intestine 54(48.2) 17(23.6) 0.001 * 3.012 1.560-5.817 Vagina 25(22.3) 6(8.3) 0.013 * 3.161 1.226-8.164 Posterior fornix 11(9.8) 12(16.7) 0.171 0.545 0.226-1.311 Ureter 15(13.4) 14(19.4) 0.272 0.641 0.289-1.423 Fallopian tube 10(8.9) 9(12.5) 0.437 0.686 0.264-1.781 Rectovaginal pouch 11(9.8) 12(16.7) 0.171 0.545 0.226-1.311 a Values are shown as mean ± standard deviation or N(%). * Statistically significant Cite Share Download PDF Status: Published Journal Publication published 20 May, 2020 Read the published version in BMC Women's Health → Version 1 posted Editorial decision: Major revision 04 Feb, 2020 Review # 4 received at journal 24 Jan, 2020 Review # 3 received at journal 24 Jan, 2020 Reviewer # 7 agreed at journal 04 Jan, 2020 Reviewer # 5 agreed at journal 30 Dec, 2019 Review # 6 received at journal 30 Dec, 2019 Review # 5 received at journal 30 Dec, 2019 Review # 2 received at journal 30 Dec, 2019 Review # 1 received at journal 30 Dec, 2019 Reviewer # 6 agreed at journal 30 Dec, 2019 Reviewer # 4 agreed at journal 30 Dec, 2019 Reviewer # 3 agreed at journal 30 Dec, 2019 Reviewer # 2 agreed at journal 30 Dec, 2019 Reviewer # 1 agreed at journal 30 Dec, 2019 Reviewers invited by journal 30 Dec, 2019 First submitted to journal 19 Dec, 2019 Editor assigned by journal 19 Dec, 2019 Editor invited by journal 18 Dec, 2019 Submission checks completed at journal 18 Dec, 2019 You are reading this older preprint version Read the latest preprint version → Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-10476","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":273254,"identity":"049dd29d-fcbc-48d7-bcee-14960f933293","order_by":1,"name":"Hungling Kwok","email":"","orcid":"","institution":"the Seventh Affiliated Hospital, Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Hungling","middleName":"","lastName":"Kwok","suffix":""},{"id":273255,"identity":"69119feb-173e-4f23-b6ef-d13c4d05e48b","order_by":2,"name":"Hongye Jiang","email":"","orcid":"","institution":"Sun Yat-sen University First Affiliated Hospital","correspondingAuthor":false,"prefix":"","firstName":"Hongye","middleName":"","lastName":"Jiang","suffix":""},{"id":273256,"identity":"46c3e50c-97ab-4b14-829a-fd1db4bc9269","order_by":3,"name":"Tian Li","email":"","orcid":"","institution":"the Seventh Affiliated Hospital, Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Tian","middleName":"","lastName":"Li","suffix":""},{"id":273257,"identity":"cc7ae271-2dd6-4a30-9495-68d310df74b4","order_by":4,"name":"Huan Yang","email":"","orcid":"","institution":"the seventh Affiliated Hospital, Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Huan","middleName":"","lastName":"Yang","suffix":""},{"id":273258,"identity":"9257c073-c8db-49ba-b0b5-572b5c04f54b","order_by":5,"name":"Hui Fei","email":"","orcid":"","institution":"the Seventh Affiliated Hospital, Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Hui","middleName":"","lastName":"Fei","suffix":""},{"id":273259,"identity":"12c8966c-76cb-4e11-926c-274849912b4e","order_by":6,"name":"Li Cheng","email":"","orcid":"","institution":"the Seventh Affiliated Hospital, Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Li","middleName":"","lastName":"Cheng","suffix":""},{"id":273260,"identity":"1a29f25d-3eec-48bc-a84a-e1773712cd5e","order_by":7,"name":"Shuzhong Yao","email":"","orcid":"","institution":"Sun Yat-sen University First Affiliated Hospital","correspondingAuthor":false,"prefix":"","firstName":"Shuzhong","middleName":"","lastName":"Yao","suffix":""},{"id":273261,"identity":"2e2c3dfe-da4d-405e-88bb-5c8a2af14911","order_by":8,"name":"Shu-Qin Chen","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA70lEQVRIie3RsYrCMBjA8ZRCXVKyplTf4YOCh5x4r1IR7FLQR0gJZLw54uBbHI4pASfRVdDBLs51EQQHA+JwyMWON+RPErL8SEIQcrn+Y9RMjyEUmFXV0MeEsMbELyo5HbcjqRoShFo8wbXuA0vtgsz5qroudec7LgTFsMWAlFefc8shh1WWhGudiHYpKIU9/vCZH81+/iZA827sCT0U1AwwpMdU4IdWMrlE1ydJYYNBpe9IHtDwQTgoUO8J3Y27cSiyxJCiYjDCkSy59S1Ejk7mYp+dhcyO+nYbfBHCy/psIc8eX/O6b0hcLpfL9bs7myJUfGSmWOgAAAAASUVORK5CYII=","orcid":"","institution":"Sun Yat-sen University First Affiliated Hospital","correspondingAuthor":true,"prefix":"","firstName":"Shu-Qin","middleName":"","lastName":"Chen","suffix":""}],"badges":[],"createdAt":"2019-12-28 13:53:53","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.19864/v1","doiUrl":"https://doi.org/10.21203/rs.2.19864/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12905-020-00974-y","type":"published","date":"2020-05-20T18:24:24+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":780743,"identity":"e4cbe41b-693b-48f3-ba8f-5ab7f67c6b9e","added_by":"auto","created_at":"2020-03-30 22:29:11","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":60699,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-10476/v1/manuscript.pdf"},{"id":317268,"identity":"d14fb801-5e8a-4013-a0d0-b17fea22b43e","added_by":"auto","created_at":"2020-01-02 17:00:45","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":223802,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/6693f2db-ea50-4bc2-8d0a-09e9d7bbecbd/v1/Manuscript.pdf"}],"financialInterests":"","formattedTitle":"Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study","fulltext":[{"header":"Full Text","content":"\u003cp\u003eThis preprint is available for \u003ca href='/article/rs-10476/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTable \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eI \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePreoperative characteristics of the study population\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 325.6pt; border-collapse: collapse; border: none;\" width=\"434\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 17.7pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.7pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePatients\u0026rsquo; characteristics (N= \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e304\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.7pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eValues\u003csup\u003e a\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eAge(years)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e34.2\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e5.8\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(range17-49)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eParity\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Para\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026ge;1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e158(52.0\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Nulliparous\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e146(48.0\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Infertility\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e78(25.7\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eP\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003erevious surgery for OEM\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e88(28.9\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePresenting symptoms\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; No symptoms\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e32(10.5\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Dysmenorrhea\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e272(89.5\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; D\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eyspareunia\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e39(12.8\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.0pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eChronic pelvic pain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e17(5.6\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 18.35pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.35pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black; background: white;\"\u003eAnus bulge\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.35pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e73(24.0\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eDifficulty in defecation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e13(4.3\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.95pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.95pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Diarrhea\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.95pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e6(2.0\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Defecation pain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e11(3.6\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Hematochezia\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e8(2.6\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Urinary frequency and urgency\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e9(3.0\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Haematuria\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2(0.7\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; H\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eydronephrosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e26(8.6\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eEndometrioma laterality\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Left\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e98(32.2\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.25pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Right\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e86(28.3\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.25pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eBilateral\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e120(39.5\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e%\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eEndometrioma size (mm)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e55.9\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e23.9\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e (range10-150)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 205.1pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"273\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eNumber of DIE lesions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.60\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e1.5 (range1-9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003eOEM, ovarian endometrioma; DIE, deep infiltrating endometriosis.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003eValues are shown as mean \u003c/span\u003e\u003cspan style=\"font-size: 10.5pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003e standard deviation or N(%).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003eDifferent symptoms can be associated in the same patient.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTable II The prevalence of \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ea\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003enatomical distribution of DIE lesions. (n=304 patients)\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"442\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eMain lesion\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eNumber of patients(%)\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUterosacral ligament \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e245(80.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Left \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Right \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Bilateral \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e135\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eRectum \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e93(30.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.65pt;\"\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUreter \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e47(15.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Left \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e22\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.95pt;\"\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.95pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Right \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.95pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e18\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Bilateral\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eVaginal \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e40(13.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePosterior fornix \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e33(10.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eFallopian tube \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e29(9.54)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Left \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Right \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eBilateral\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eVaginal rectum \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e21(6.91)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eRectovaginal pouch\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e9(2.96)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 205.55pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"274\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eBladder\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 125.9pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"168\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e4(1.32)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify; text-justify: inter-ideograph;\"\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003eDIE, deep infiltrating endometriosis.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify; text-justify: inter-ideograph;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.5pt; color: #333333;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 10.5pt; color: #333333;\"\u003eAccording to the location of the lesion recorded during the operation.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify; text-justify: inter-ideograph;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.5pt; color: #333333;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 10.5pt; color: #333333;\"\u003eNumber of patients whose lesions histologically proven deep infiltrating endometriosis.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify; text-justify: inter-ideograph;\"\u003e\u003cspan style=\"font-size: 10.5pt; color: #333333;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify; text-justify: inter-ideograph;\"\u003e\u003cspan style=\"color: #333333;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333;\"\u003eTable III \u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eCharacteristics of deeply infiltrating endometriosis lesion distribution associated ovarian endometrioma.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 411.2pt; margin-left: 5.3pt; border-collapse: collapse; border: none;\" width=\"548\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 52.5pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 52.5pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eVariables\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.5pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 52.5pt;\" colspan=\"2\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eComparison\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 52.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e-value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 52.5pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eOR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 52.5pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e95% CI\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.3pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: dashed windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.3pt;\" rowspan=\"2\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.5pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: dashed windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.3pt;\" colspan=\"2\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eOEM laterality\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 181.55pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: dashed windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.3pt;\" colspan=\"3\" rowspan=\"2\" width=\"242\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.25pt;\"\u003e\n\u003ctd style=\"width: 57.9pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUnilateral\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003en=184\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border-top: dashed windowtext 1.0pt; border-left: none; border-bottom: dashed windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eBilateral\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003en=120\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eNumber of DIE lesions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.76\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333;\"\u003e1.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.33\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333;\"\u003e1.34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.006\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.3pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUterosacral ligament\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e151(82.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e94(78.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.421\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.266\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.712-2.249\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eIntestine \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e72(39.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e21(17.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e3.031\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.738-5.286\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eVagina\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e32(17.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e8(6.70)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.007\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.947\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.308-6.641\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePosterior fornix\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e23(12.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e10(8.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.100\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.571\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.720-3.431\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUreter\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e29(15.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e18(15.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.858\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.060\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.560-2.009\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.25pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eFallopian tube\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e19(10.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e10(8.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.563\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.267\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.568-2.827\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.65pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eRectovaginal pouch\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"77\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e16(8.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"74\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e14(11.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.396\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"57\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.767\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.359-1.637\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 23.8pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.8pt;\" rowspan=\"2\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.5pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.8pt;\" colspan=\"2\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eSide of OEM\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 181.55pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.8pt;\" colspan=\"3\" rowspan=\"2\" width=\"242\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 27.45pt;\"\u003e\n\u003ctd style=\"width: 57.9pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 27.45pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003eLeft side\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003en=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e98(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border-top: dashed windowtext 1.0pt; border-left: none; border-bottom: dashed windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 27.45pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003eRight side\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003en=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003e86\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eNumber of DIE lesions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.83\u0026plusmn;1.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.74\u0026plusmn;1.53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.678\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUterosacral ligament\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e81(82.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e70(81.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.824\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.089\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.512-2.315\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eIntestine\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e40(40.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e32(37.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.617\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.164\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.642-2.109\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eVagina\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e18(18.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e15(17.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.870\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.065\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.500-2.268\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePosterior fornix\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e15(15.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e8(9.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.219\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.762\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.078-4.386\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUreter\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e16(16.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e13(15.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.822\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.096\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.494-2.431\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eFallopian tube\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e8(8.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e11(12.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.303\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.606\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.232-1.584\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eRectovaginal pouch\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e9(9.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e7(8.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.802\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.141\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 1.0pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.406-3.207\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 23.4pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.4pt;\" rowspan=\"2\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.5pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.4pt;\" colspan=\"2\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUnilateral OEM size\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 181.55pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.4pt;\" colspan=\"3\" rowspan=\"2\" width=\"242\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 27.3pt;\"\u003e\n\u003ctd style=\"width: 57.9pt; border: none; border-bottom: dashed windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 27.3pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003e\u0026le;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e50mm\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003en=112\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border-top: dashed windowtext 1.0pt; border-left: none; border-bottom: dashed windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 27.3pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003e\u0026gt;50mm\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003en=72\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eNumber of DIE lesions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.77\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e1.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e2.82\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e1.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.960\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.3pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUterosacral ligament\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e87(77.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e64(88.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.053\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.435\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.3pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.184-1.027\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eIntestine\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e54(48.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e17(23.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.001\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e3.012\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.560-5.817\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eVagina\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e25(22.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e6(8.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.013\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e3.161\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.226-8.164\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePosterior fornix\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e11(9.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e12(16.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.171\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.545\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.226-1.311\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eUreter\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e15(13.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e14(19.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.272\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.641\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.289-1.423\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.25pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eFallopian tube\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e10(8.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e9(12.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.437\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.686\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.25pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.264-1.781\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.15pt;\"\u003e\n\u003ctd style=\"width: 116.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.15pt;\" width=\"155\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eRectovaginal pouch\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.9pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.15pt;\" width=\"77\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e11(9.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 55.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.15pt;\" width=\"74\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e12(16.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.15pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.171\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.15pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.545\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 90.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.15pt;\" width=\"121\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.226-1.311\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003eValues are shown as mean \u003c/span\u003e\u003cspan style=\"font-size: 10.5pt; font-family: Symbol; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.5pt; color: black;\"\u003e standard deviation or N(%).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.5pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 10.5pt;\"\u003eStatistically significant\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"ovarian endometrioma, deep infiltrating endometriosis, lesion distribution characteristics","lastPublishedDoi":"10.21203/rs.2.19864/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.19864/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003ePurpose: To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM). \u003c/p\u003e\u003cp\u003eMethods:The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Clinical data were recorded for each patient from medical, operative and pathological reports. Patients were then divided into two groups according to unilateral or bilateral OEM. Patients with unilateral OEM were subsequently divided into two subgroups according to OEM location (left- or right-hand side) and the diameter of the OEM (≤50 and \u0026gt;50 mm). The distribution characteristics of DIE lesions were then compared between the groups. \u003c/p\u003e\u003cp\u003eResults:DIE lesions were widely distributed, 30 anatomical sites were involved. Patients with associated unilateral OEM (n=184 patients) had a significantly increased number of DIE lesions when compared with patients with bilateral OEM (n=120 patients; 2.76±1.52 vs. 2.33±1.34; P=0.006). Compared with bilateral OEM with DIE, there was a higher rate of intestinal (39.1% vs. 18.3%; P\u0026lt;0.01) and vaginal (17.4% vs. 6.7%; P\u0026lt;0.01) infiltration by DIE lesions in unilateral OEM with DIE. The mean number of DIE lesions was not significantly correlated with the location or size of the OEM (2.83±1.56 vs. 2.74±1.53; P=0.678; and 2.65±1.42 vs. 2.80±1.43; P=0.518, respectively). There was no significant difference between the groups with OEM ≤50 mm and \u0026gt;50 mm. \u003c/p\u003e\u003cp\u003eConclusion:Lesion distribution characteristics in women diagnosed with histologically proven OEM associated with DIE were frequently multifocal and severe. \u003c/p\u003e","manuscriptTitle":"Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-03-23 14:36:22","doi":"10.21203/rs.2.19864/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2020-04-19T12:00:00+00:00","index":5,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThanks for your answers.* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"decision","content":"Minor revision","date":"2020-04-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-04-14T12:00:00+00:00","index":4,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nmanuscript does not require any further revisions and all issues have been adequately addressed by authors' response* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **Not relevant to this manuscript**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"reviewerAgreed","content":"","date":"2020-03-22T12:00:00+00:00","index":5,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-03-18T12:00:00+00:00","index":3,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-03-18T12:00:00+00:00","index":3,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"reviewerAgreed","content":"","date":"2020-03-18T12:00:00+00:00","index":4,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-03-17T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-03-17T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-03-17T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-03-17T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-03-17T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after discretionary revisions\nForm responses:\n---\n\nComments to Author:\n---\nHowever:\n- I do not agree with what they point out about the symptom dyspareunia: \"There are no corresponding relationship between dyspareunia and DIE lesions in ligaments, vaginal, posterior fornix, etc. The presence of these lesions is often associated with dysmenorrhea\". I believe that deep dyspareunia is the most specific symptom in women with DIE (if they have sexual intercourse) and corresponds to the pain induced by vaginal touch in the Douglas cul de sac and in the touch of nodules like pellets on the uterosacral ligaments.\n- You should review the bibliographic citations in the text: \"Indeed, Maria et al. [11] created a predictive model…\" \"Diego Raimondo et al. [27] pointed…\". Maria is de name (M) \"11. Perello, M., et al., Markers .. \" and it should also be Raimondo D.\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **Not relevant to this manuscript**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"editorInvitedReview","content":"","date":"2020-03-17T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nthe authors answered the questions adequately.\nplease consider the first author for reference number 27 in the manuscript (Mabrouk et al.)* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"checksComplete","content":"","date":"2020-03-16T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-03-16T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-01-02 17:00:35","doi":"10.21203/rs.2.19864/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-02-04T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-01-24T12:00:00+00:00","index":4,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n\nComments to Author:\n---\nThe aim of study of Kwok et al. was to investigate the characteristic of deep infiltrating endometriosis lesion distribution when associated with ovarian endometrioma.\nThe study is very interesting, all the more, it brings a new direction to the diagnostics of endometriosis. However, I have a few questions:\n\n1.Have you considered use the ENZIAN classification of DIE? Can it together with yours results be useful to create map of DIE?\n2.In what phase of the menstrual cycle the surgery was performed?\n3.Except for these changes, were another lesion in peritoneal cavity? Superficial endometriosis? adhesion?\n4.Almost 90% of studied women had previously surgery for OEM, did they have any additional pharmacological treatment?\nCould you check, did the previous operation concern the same places?\n5.It could be more useful when you present results on figures.\n6.In Discussion part, it is not clear, where is your observations or conclusions and observations from other Authors.\n"},{"type":"editorInvitedReview","content":"","date":"2020-01-24T12:00:00+00:00","index":3,"fulltext":"Recommendation: Reject\nForm responses:\n---\n* Are the methods appropriate and well described?: **No**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **Unable to assess**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Needs some language corrections before being published**\n* Declaration of competing interests: **declare that I have no competing interests**\n\nComments to Author:\n---\nThe patient records of 304 patients operated by a single surgeon in a single center were evaluated retrospectively.\nPatient who had both ovarian endometriosis as well as deep infiltrating endometriosis were evaluated.\nMedical, surgical and pathological records were evaluated. There are several important data missing from the manuscript.\n\nIt would appear that the patients were carefully evaluated before the surgery as the extensive preoperative tests included transvaginal sonography, urological ultrasound as well as MRI.\nThe symptoms are carefully listed, however nothing is mentioned about the medical treatment that the patients received prior to the surgery. In most (if not all ) guidelines the medical treatment should be the primary form of treatment and only if no sufficieint relief is observed then surgical interventions should be used.\n\nIt appears that during the period of 2008 - 2016 a large number of cases with ovarian disease only may have /(probably) have been operated. How many cases of unilateral ovarian endometriosis with no DIE were operated during that period? How many cases of bilateral cases of ovarian endometriosis with no DIE were operated during that period? How many of these were symptom less or had very little symptoms (compared to the one with DIE), This was enable the evaluation of the importance of symptoms in suspicion of DIE. Whereas the symptoms have been documented, there is no effort to find an association with specific symptoms and the location of the DIE. Not being familiar with the Chinese patient records and the reliability of details it is not possible to estimate whether this could be possible, certainly in many centers the routine surgical and medical notes are unlikely to give reliable and detailed information on this important issues.\nAs the goal in the study is to investigate the association between DIE and unilateral and bilateral OEM why has the imaging been completely ignored in this study? Would the findings be different if the analysis was done solely based on the imaging findings? Did the imaging findings match the surgical findings?"},{"type":"reviewerAgreed","content":"","date":"2020-01-04T12:00:00+00:00","index":7,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-12-30T12:00:00+00:00","index":5,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-12-30T12:00:00+00:00","index":6,"fulltext":"Recommendation: Accept after discretionary revisions\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **No**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n\nComments to Author:\n---\nThank you for giving me the opportunity to review this interesting study \"Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study\".\nHowever, I have some comments and recommendations:\nComments:\nTitle:\n- Is appropriate for the content of the article.\nAbstract:\n- Represents a suitable summary of the work.\nArticle content:\n- The design, methods and analysis of the results are appropriate for the study.\nConclusions:\n- Are justified on the basis of the results of the study.\nRecommendations:\nIntroduction:\n- Emphasize the relation between OEM and DIE.\nMethods:\n- Mention appropriate details of surgical techniques.\nResults:\n- Do not duplicate, the text should complement the tables.\nDiscussion:\n- Mention the limitations of the study.\nReferences:\n- Update some references.\nGeneral:\n- Revise language, grammar and syntax.\n"},{"type":"editorInvitedReview","content":"","date":"2019-12-30T12:00:00+00:00","index":5,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **Not relevant to this manuscript**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n\nComments to Author:\n---\nWell-designed study that investigated the characteristics of the lesion distribution in ovarian endometrioma patients with deep infiltrating endometriosis"},{"type":"editorInvitedReview","content":"","date":"2019-12-30T12:00:00+00:00","index":2,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **No**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Needs some language corrections before being published**\n* Declaration of competing interests: **no competing interests to declare**\n\nComments to Author:\n---\n\nThe Authors performed a good analysis on a very interesting topic in endometriosis management. However, further details are needed in the Results and Discussion section.\n\n1. The title is clear and accurately reflects the study contents\n\n2. Introduction:\na. The description of the background is correct.\nb. main objective: what do you mean with \"When do OEM patients also develop DIE?\". Please explain better.\n\n\n3. Materials and methods:\na. Study design is well mentioned.\nb. Could you perform a sample size or power analysis calculation?\nc. Population: overall seems appropriate. Data about previous surgery for deep endometriosis and preoperative medical therapy lack. Please add;\nWhy were patients operated on?\nd. Outcomes: well documented; data about ileocecal and appendiceal involvement lack. Please add some data about ileoceal and appendiceal endometriosis and discuss with adequate reference in the discussion (i.e. Mabrouk M et al. Endometriosis of the Appendix: When to Predict and How to Manage-A Multivariate Analysis of 1935 Endometriosis Cases. J Minim Invasive Gynecol. 2020).\n\ne. Description: well done.\n\nf. Statistics: Appropriately described\n\n\n4. Results:\na. Tables and figures are overall easy to understand.\nTable 1: what do you mean with \"anus bulge\"? It is so frequent in your endoemtriotic patients? Why?\nTable 2: What do you mean with \"Vaginal rectum\"?\n\nb. I. Clarity of results: seems appropriate.\n\nii. Reported objectives: deep lesion distribution and characteristics according to OMA presentations.\n\niii. Clinical interpretability: Seems appropriate\n\n5. Discussion:\na. Clinical relevance: addressed.\n-Please modify the paragraph including lines 166-171:\n\" Some researchers have suggested that urinary tract endometriosis may occur more frequently than it is currently thought to, particularly in patients with DIE\" Urinary tract endometriosis is a part of DIE, it is not? Please clarify this sentence.\n\"In this case, when there is an associated OEM, ultrasonic examination of the urogenital system is necessary.\"\nIn accordance with previous study (i.e. Raimondo D et al. Severe ureteral endometriosis: frequency and risk factors. J Obstet Gynaecol. 2018 Feb;38(2):257-260) the Authors found an association between the presence of OMA and ureteral involvement by the disease. Please add some references.\n\" Ureteral endometriosis should be considered when B mode ultrasound reveals ureter straitness and hydronephrosis. If the ureters are involved, renal function should be assessed by intravenous pyelography\". Please modify.\nWe perform renal scintigraphy to evaluate renal function in case of hydronephrosis. Hydroureter and hydronephrosis are the severe forms of ureteral endometriosis (Knabben et al., 2015. Urinary tract endometriosis in patients with deep infiltrating endometriosis: prevalence, symptoms, management, and proposal for a new clinical classification); the mild forms can be diagnosed also using uroCT or uroMRI and in many cases only during retroperitoneal dissection .\nIt is better to say \"stricture\" or \"stenosis\".\n- Please explain better why monolateral endometrioma are more associated to bowel and vaginal endometriosis. Please remove the paragraph including lines 184-190. It is not in line with the study aim.\n\nb. Strengths of the study: addressed\nc. Limitations of the study: not addressed. Please add.\nd. Recommendations for further research: not addressed. Please add.\n\n\n6. Abstract: Seems appropriate\n\n\n7. Grammar, overall flow, etc comments:\nI suggest to reduce length of discussion.\n"},{"type":"editorInvitedReview","content":"","date":"2019-12-30T12:00:00+00:00","index":1,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n* Are the methods appropriate and well described?: **Unable to assess**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **Unable to assess**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **Not relevant to this manuscript**\n* Quality of written English: **Needs some language corrections before being published**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n\nComments to Author:\n---\nThis is an observational study on the distribution of DIE lesions in a large number of patients (n = 304) with OEM, and all operated by one of the authors (S. Yao). They observed these DIE lesions in up to 30 anatomical sites. However, they are cited: vagina, posterior fornix, vaginal rectum and rectovaginal pouch, as different seating sites for DIE implants and I cannot clarify these locations.\nThe results show that there were more DIE lesions among women with unilateral OEM, especially intestinal (¿), which seems logical as the other OEM does not prevent its display. There were no other significant differences between the OEM groups.\nBut I also have some doubts:\n1. Why were cases with laparoscopic surgery converted to open surgery excluded?\n2. The correspondence of the location of the lesions that I mentioned before: rectum, vaginal rectum, rectovaginal pouch ?, should be clarified.\n3. The importance of the complete exeresis of all DIE lesions is strongly insisted, don't you think that, as Dmowski said many years ago, counting the number of endometriosis lesions is like counting the number of spots of disseminated lupus erythematosus to see its severity ?, do the recurrences correspond to the implants without a complete exeresis ?.\n4. How do you explain that DIE implants are so frequent in uterosacral ligaments (80.6%), vaginal, posterior fornix ?, etc, the DYSPAREUNIA symptom is only present in 12.8% of patients? And chronic pelvic pain in 5.6% ?.\n"},{"type":"reviewerAgreed","content":"","date":"2019-12-30T12:00:00+00:00","index":6,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-12-30T12:00:00+00:00","index":4,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-12-30T12:00:00+00:00","index":3,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-12-30T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-12-30T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-12-30T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2019-12-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-12-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-12-18T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2019-12-18T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ccdf377d-9be8-49a8-b05a-8864e9e1477b","owner":[],"postedDate":"January 2nd, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":46141,"name":"Obstetrics \u0026 Gynecology"}],"tags":[],"updatedAt":"2021-09-27T18:29:18+00:00","versionOfRecord":{"articleIdentity":"rs-10476","link":"https://doi.org/10.1186/s12905-020-00974-y","journal":{"identity":"bmc-womens-health","isVorOnly":false,"title":"BMC Women's Health"},"publishedOn":"2020-05-20 18:24:24","publishedOnDateReadable":"May 20th, 2020"},"versionCreatedAt":"2020-01-02 17:00:35","video":"","vorDoi":"10.1186/s12905-020-00974-y","vorDoiUrl":"https://doi.org/10.1186/s12905-020-00974-y","workflowStages":[]},"version":"v1","identity":"rs-10476","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-10476","version":["v1"]},"buildId":"WvIrzKhiLBfengagbw6Ux","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}
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