Changing the paradigm of endometriosis - from diagnosis to integrated long-term management: a joint society opinion paper

Charles Chapron, Chapron C, Guillaume Parpex, Thierry Van den Bosch, van den Bosch T, Al-Hendy A, Ayman Al Hend, Ayman Al-Hendy, Gargiulo A, Antonio Gargiulo, Stockwell E, Erica Stockwell, Hugh S. Taylor, Hugh Taylor, Taylor HS, Steven McCarus, McCarus S, Petraglia F, Felice Petraglia, Society of Endometriosis and Uterine Disorders (SEUD) and American Institute for Minimally Invasive Surgery (AIMIS)
Reproductive BioMedicine Online · 2026 · vol. 53(1) , pp. 105642 · doi:10.1016/j.rbmo.2026.105642 · PMID:42140173 · W7131242589
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper redefines endometriosis care by emphasizing clinical assessment and imaging for diagnosis, progestins as first-line medical therapy, and reserving surgery for specific indications followed by hormonal suppression.

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Abstract

Endometriosis is a chronic, systemic, oestrogen-dependent disease with major impacts on pain, fertility and quality of life. This Society of Endometriosis and Uterine Disorders and American Institute for Minimally Invasive Surgery opinion synthesizes current evidence to redefine diagnostic and therapeutic strategies across the continuum of care. Diagnostic laparoscopy is no longer indicated, as clinical assessment combined with expert transvaginal ultrasonography and magnetic resonance imaging reliably identifies disease phenotypes and guides management. Medical therapy, particularly progestins, remains the foundation of long-term care, with gonadotrophin-releasing hormone analogues and antagonists as second-line options. Surgery is reserved for clearly defined indications - including deep infiltrating disease, infertility with correctable anatomy and organ-threatening involvement - and must be preceded by comprehensive imaging and followed by prolonged hormonal suppression to reduce recurrence. Integrated, individualized care pathways are essential to improve outcomes and support fertility preservation. This framework represents a modern paradigm for comprehensive endometriosis management.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (2)

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