Association of embryo transfer type with infertility in endometriosis: a systematic review and meta-analysis
A meta-analysis of six studies found frozen embryo transfer resulted in significantly higher live birth rates and lower miscarriage rates compared to fresh embryo transfer in women with endometriosis.
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This systematic review and meta-analysis evaluated whether frozen embryo transfer improves assisted reproductive technology outcomes compared with fresh embryo transfer in women with a history of endometriosis, including studies through January 10, 2021 and synthesizing data from the first transfer cycle only. Across six studies (3010 women; 1777 frozen vs 1233 fresh) with moderate methodological quality, frozen embryo transfer was associated with higher live birth frequency (OR 1.53, 95% CI 1.13–2.08) and a lower miscarriage rate (OR 0.70, 95% CI 0.50–0.97), while clinical pregnancy rates were not significantly different. The authors noted that the evidence base was not abundant and that more strictly designed research is needed. This paper is centrally about endometriosis — it directly meta-analyzes embryo transfer type (frozen-thawed vs fresh) on infertility and reproductive outcomes in endometriosis patients.
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Cited by (10)
- Changing the paradigm of endometriosis – from diagnosis to integrated long-term management: a joint society opinion paper 2026
- Endometriosis-associated infertility: Multi-omics insights into pathogenesis and precision therapeutics 2025
- Comparison of clinical pregnancy rates and miscarriage rates in frozen vs selective fresh embryo transfers: a multicentric retrospective analysis 2025
- Improving reproductive outcomes in frozen embryo transfer over fresh embryo transfer in women with endometrioma: A historical cohort study 2025
- Reproductive outcomes in women with advanced endometriosis in fresh versus frozen embryo transfer cycles 2024
- Reproductive outcomes in women with advanced endometriosis in fresh versus frozen embryo transfer cycles. 2024
- Aktualisierung der Endometriose-Leitlinie 2024
- Evidence based management of patients with endometriosis undergoing assisted conception: British fertility society policy and practice recommendations 2024
- Retrospective analysis of the endometrial preparation protocols for frozen-thawed embryo transfer cycles in women with endometriosis 2023
- Infertilidad asociada a endometriosis. Revisión bibliográfica 2023
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