Adenosine triphosphate-binding cassette transporter G2 expression in endometriosis and in endometrium from patients with and without endometriosis

Matsuzaki S, Sachiko Matsuzaki, Claude Darcha, Darcha C
Fertility and sterility · 2012 · vol. 98(6) , pp. 1512–1520.e3 · doi:10.1016/j.fertnstert.2012.07.1133 · PMID:22925688 · W1979508091
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This study investigated the expression of the ATP-binding cassette transporter G2 (ABCG2) in endometriosis lesions and in endometrial tissue from patients with and without endometriosis.

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Abstract

OBJECTIVE: To investigate adenosine triphosphate (ATP)-binding cassette transporter G2 (ABCG2) expression in endometriosis and in samples of endometrium from patients with and without endometriosis. DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): Patients with and without endometriosis. INTERVENTION(S): Endometrial and endometriotic tissues obtained throughout the menstrual cycle. MAIN OUTCOME MEASURE(S): Density of ABCG2(+) microvessels, density of CD31(+) microvessels. RESULT(S): No statistically significant differences in the density of ABCG2(+) microvessels were observed between endometrium of patients with and without endometriosis in the proliferative phase and early, middle, and late secretory phases. The density of ABCG2(+) microvessels was statistically significantly higher in the menstrual endometrium of patients with endometriosis compared with patients without endometriosis. The density of ABCG2(+) microvessels was reduced in the ectopic endometrium compared with matched eutopic endometrium except in cases of deep infiltrating endometriosis. The density of ABCG2(+) microvessels was statistically significantly higher in deep infiltrating endometriosis compared with ovarian endometriosis and red and black peritoneal lesions throughout the menstrual cycle. CONCLUSION(S): ABCG2 is strongly expressed in the endothelial cells of microvessels of eutopic endometrium, and the density of ABCG2(+) microvessels is reduced in ectopic endometrium except in cases of deep infiltrating endometriosis. ABCG2(+) microvessels may represent an integral part of the pathophysiology of deep infiltrating endometriosis.

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Condition tags

endometriosis

MeSH descriptors

ATP-Binding Cassette Transporters Endometriosis Endometrium Neoplasm Proteins ATP-Binding Cassette Transporters ATP-Binding Cassette Transporters ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP Binding Cassette Transporter, Subfamily G, Member 2 Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Neoplasm Proteins Neoplasm Proteins Organ Specificity Organ Specificity

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (10)

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