Adenosine Triphosphate Regresses Endometrial Explants in a Rat Model of Endometriosis

Chen Zhang, Li Gao, Yanhong Yi, Hongjing Han, Hongyan Cheng, Xue Ye, Ruiqiong Ma, Kunkun Sun, Heng Cui, Xiaohong Chang
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 23(7) , pp. 924–930 · doi:10.1177/1933719115625847 · W2287947295
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Adenosine triphosphate reduced endometriotic explant size in rats while not affecting eutopic endometrial stromal cell proliferation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigated whether adenosine triphosphate (ATP) can regress endometrial explants in a rat model of endometriosis and whether ATP affects proliferation of eutopic endometrium stromal cells. After surgical induction of endometriosis, rats were treated with intragastric normal saline, gestrinone, ATP (3.4 mg/kg/d IG), or ATP (1.0 mg/kg/d intramuscular), and explant and eutopic uterine histology were assessed after four weeks; proliferation of human endometrial stromal hEM15A cells was measured over 24–72 hours using a CCK-8 assay. ATP administration increased explant regression compared with controls (notably higher regression in the intramuscular ATP group with similar pretreatment implant sizes), and epithelial preservation was better in saline than in ATP groups, while hEM15A proliferation showed no significant ATP-related difference versus controls. The paper does not explicitly address limitations in the abstract, but it relies on a small in vivo sample size (3 killed at baseline, with remaining rats split across groups) and an in vitro proliferation readout of a single stromal cell line. This paper is centrally about endometriosis—testing ATP’s ability to regress endometrial explants in a rat endometriosis model.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adenosine Triphosphate Endometriosis Adenosine Triphosphate Animals Cell Line Cell Proliferation Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Rats Rats, Sprague-Dawley Stromal Cells Stromal Cells Stromal Cells

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