Fertility before and after surgery for deep infiltrating endometriosis with and without bowel involvement: a literature review

J. Cohen, Cohen J, Jérémie F. Cohen, Thomin A, A. Thomin, Mathieu d'Argent E, Emmanuelle Mathieu d’Argent, E Mathieu d'Argent, E Laas, Enora Laas, Laas E, G Canlorbe, Canlorbe G, Geoffroy Canlorbe, Zilberman S, Sonia Zilberman, S Zilberman, J. Belghiti, Belghiti J, Thomassin-Naggara I, I Thomassin-Naggara, Marc Bazot, Bazot M, M Bazot, M Ballester, Marta Ballester, Ballester M, Émile Daraï, Daraï E, E. Daraï
Minerva ginecologica · 2014 · vol. 66(6) , pp. 575–87 · PMID:25373015 · W2337700291
Review OA: closed CC0 ⤵ 58 in-corpus citations
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Surgery alone achieved a 50.5% spontaneous pregnancy rate for deep infiltrating endometriosis without bowel involvement, while bowel involvement surgery combined with MAR yielded a 46.9% overall rate.

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Abstract

AIM: Endometriosis affects from 10% to 15% of women of childbearing age and 20% of these women have deep infiltrating endometriosis (DIE). The goal of this review was to assess the impact of various locations of DIE on spontaneous fertility and the benefit of surgery and Medically Assisted Reproduction (MAR) (in vitro fertilization and intrauterine insemination) on fertility outcomes. METHODS: MEDLINE search for articles on fertility in women with DIE published between 1990 and April 2013 using the following terms: "deep infiltrative endometriosis", "colorectal", "bowel", "rectovaginal", "uterosacral", "vaginal", "bladder" and "fertility" or "infertility". Twenty-nine articles reporting fertility outcomes in 2730 women with DIE were analysed. RESULTS: Among the women with DIE and no bowel involvement (N.=1295), no preoperative data on spontaneous pregnancy rate (PR) were available. The postoperative spontaneous PR rate in these women was 50.5% (95% Confidence Interval [CI] =46.8-54.1) and overall PR (spontaneous pregnancies and after MAR) was 68.3% (95% CI=64.9-71.7). No evaluation of fertility outcome according to locations of DIE was feasible. For women with DIE with bowel involvement without surgical management (N.=115), PR after MAR was 29%; 95% CI=20.7-37.4). For those with bowel involvement who were surgically managed (N.=1320), postoperative spontaneous PR was 28.6% (95% CI=25-32.3) and overall postoperative PR was 46.9% (95% CI=42.9-50.9). CONCLUSION: For women with DIE without bowel involvement, surgery alone offers a high spontaneous PR. For those with bowel involvement, the low spontaneous and relatively high overall PR suggests the potential benefit of combining surgery and MAR.

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Condition tags

endometriosisdie_deep_infiltratinginfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Infertility, Female Endometriosis Endometriosis Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Humans Humans Infertility, Female Infertility, Female Infertility, Female Intestinal Diseases Intestinal Diseases Intestinal Diseases Intestinal Diseases

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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