Association between the level of TGF- β expression and endometriosis: A systematic review and meta-analysis

L.V. Adamyan, L.G. Pivazyan, K.K. Murvatova, Veronika Tarlakyan, Evdokiya Zarova, A.A. Stepanian, K.S. Mailova
In: Journal of Endometriosis and Uterine Disorders · 2024 · vol. 9 , pp. 100100 · doi:10.1016/j.jeud.2024.100100 · W4404516750
Systematic review / meta-analysis OA: diamond CC0 ⤵ 6 in-corpus citations
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This systematic review and meta-analysis found that transforming growth factor-beta (TGF-β) levels are higher in women with endometriosis compared to control groups, despite significant data heterogeneity.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

• Endometriosis shows significant variation in its presentation and pathophysiology and is closely linked to fibrosis. • There is a critical need to provide insights in pathophysiology of endometriosis and to find new biomarkers and targets for medical treatment. • Transforming growth factor-β is a cytokine which modulates a big variety of cellular processes including normal functioning of endometrium. • The expression of TGF-β tends to be higher in various tissues and fluids of patients with endometriosis compared to control women. The purpose of this systematic review and meta-analysis was to identify association between the level of transforming growth factor-β (TGF- β) expression in endometrial tissue, serum, peripheral blood, peritoneal fluid, peritoneum from women with endometriosis. Search was conducted in electronic databases including PubMed, The Cochrane Library, ClinicalTrials.gov, Embase, MEDLINE, Web of Science. Ten non-randomized controlled studies comparing the level of TGF- β in women with laparoscopically confirmed endometriosis and comparison group were included in quantitative synthesis. Risk-of-bias assessment tools recommended by the Cochrane Society were used to evaluate the risk of bias in the studies included. Our systematic review and meta-analysis showed that the level of TGF- β in samples from women with endometriosis is higher. However, the main limitation of our study is a high heterogeneity of published data, which was analyzed. Hence, further research is needed to provide more data with common outcomes and highlights on how to manage and treat health conditions driven by TGF- β activation and fibrosis, in particular, endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (58)

Cited by (7)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK