Clinical significance of serum follistatin levels in the diagnosis of ovarian endometrioma and benign ovarian cysts

Ömer Ant, Ant Ö, Özakşit G, Gülnur Özakşit, Güzel Aİ, Ali İrfan Güzel, Sabri Cavkaytar, Cavkaytar S, Metin Kaba, Topçu HO, Hasan Onur Topçu
Taiwanese journal of obstetrics & gynecology · 2015 · vol. 54(3) , pp. 236–239 · doi:10.1016/j.tjog.2014.03.010 · PMID:26166333 · W2112474732
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Serum follistatin levels were significantly higher in women with ovarian endometrioma compared to those with benign ovarian cysts, though CA-125 showed greater diagnostic sensitivity and specificity.

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Abstract

OBJECTIVE: To determine the clinical significance of serum follistatin levels in women with an ovarian endometrioma. MATERIALS AND METHODS: This is a prospective study of 89 women, 56 with an ovarian endometrioma (endometrioma group) and 33 with a benign ovarian cyst (control group) who underwent laparoscopic excision. Age, parity, body mass index, serum CA-125, serum CA 19-9, and serum follistatin levels were determined for all participants and evaluated as potential prognostic factors prior to laparoscopic cystectomy. RESULTS: There were no significant differences in demographic factors between the endometrioma group and the control group. However, serum follistatin levels were significantly higher in the endometrioma group (9350 ± 895 pg/mL vs. control group 725 ± 72 pg/mL, p < 0.05). The optimal diagnostic cut-off values (sensitivity and specificity) of CA-125, CA 19-9, and follistatin for ovarian endometrioma were 23.2 IU/mL (82.14% and 72.73%), 30.14 IU/mL (45.28% and 87.50%), and 2350 pg/mL (53.7% and 60.61%), respectively. CONCLUSION: Despite the increased serum follistatin levels in patients with ovarian endometrioma, CA-125 was determined to be a more sensitive and specific marker than follistatin for the diagnosis of ovarian endometrioma and endometriosis.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Follistatin Ovarian Diseases Adolescent Adult CA-125 Antigen CA-125 Antigen CA-19-9 Antigen CA-19-9 Antigen Endometriosis Endometriosis Endometriosis Female Follistatin Humans Laparoscopy Memory, Episodic Ovarian Cysts Ovarian Cysts Ovarian Cysts

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